Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. Acorus gramineus, a traditional remedy, has been studied for its anti-inflammatory and neur...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1605201/full |
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| author | Miri Park Yu-Rim Chae Hye-Bin Lee Jang-Eun Lee Jang-Eun Lee Yu Ra Lee Jinyoung Hur Ho-Young Park Ho-Young Park |
| author_facet | Miri Park Yu-Rim Chae Hye-Bin Lee Jang-Eun Lee Jang-Eun Lee Yu Ra Lee Jinyoung Hur Ho-Young Park Ho-Young Park |
| author_sort | Miri Park |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. Acorus gramineus, a traditional remedy, has been studied for its anti-inflammatory and neuroprotective effects. However, its potential role in the management of metabolic disorders via its polysaccharide components remains unclear. This study aimed to investigate the effects of the A. gramineus rhizome-derived polysaccharide (AGRP) on prebiotic potential and metabolic health in a high-fat diet-induced obesity mouse model. AGRP showed prebiotic efficacy by targeting representative intestinal microorganisms and demonstrated the ability to promote butyrate production. Importantly, mice fed a high-fat diet supplemented with AGRP showed significant improvements in metabolic disease markers, including reductions in body fat and white adipose tissue mass, compared to those in controls. Additionally, serum metabolic analysis of AGRP-administered mice demonstrated positive changes in liver enzymes, lipid profile, and glucose metabolism, as well as reduced lipid accumulation and downregulation of lipogenic genes. AGRP increased the intestinal barrier function by modulating endotoxins and tight junction protein expression, demonstrating its interaction with improved intestinal health. These findings suggest that AGRP is a promising prebiotic with potential applications in the management of MASLD and related metabolic disorders. |
| format | Article |
| id | doaj-art-70a5e654cbdb4030b307c168c80b13f0 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-70a5e654cbdb4030b307c168c80b13f02025-08-20T02:08:46ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.16052011605201Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity modelMiri Park0Yu-Rim Chae1Hye-Bin Lee2Jang-Eun Lee3Jang-Eun Lee4Yu Ra Lee5Jinyoung Hur6Ho-Young Park7Ho-Young Park8Food Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Convergence Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaFood Functionality Research Division, Korea Food Research Institute, Wanju-gun, Republic of KoreaDepartment of Food Biotechnology, University of Science and Technology, Daejeon, Republic of KoreaMetabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems. Acorus gramineus, a traditional remedy, has been studied for its anti-inflammatory and neuroprotective effects. However, its potential role in the management of metabolic disorders via its polysaccharide components remains unclear. This study aimed to investigate the effects of the A. gramineus rhizome-derived polysaccharide (AGRP) on prebiotic potential and metabolic health in a high-fat diet-induced obesity mouse model. AGRP showed prebiotic efficacy by targeting representative intestinal microorganisms and demonstrated the ability to promote butyrate production. Importantly, mice fed a high-fat diet supplemented with AGRP showed significant improvements in metabolic disease markers, including reductions in body fat and white adipose tissue mass, compared to those in controls. Additionally, serum metabolic analysis of AGRP-administered mice demonstrated positive changes in liver enzymes, lipid profile, and glucose metabolism, as well as reduced lipid accumulation and downregulation of lipogenic genes. AGRP increased the intestinal barrier function by modulating endotoxins and tight junction protein expression, demonstrating its interaction with improved intestinal health. These findings suggest that AGRP is a promising prebiotic with potential applications in the management of MASLD and related metabolic disorders.https://www.frontiersin.org/articles/10.3389/fnut.2025.1605201/fullAcorus gramineuspolysaccharidesmetabolic dysfunction-associated steatotic liver diseasemetabolic endotoxemiaprebiotic |
| spellingShingle | Miri Park Yu-Rim Chae Hye-Bin Lee Jang-Eun Lee Jang-Eun Lee Yu Ra Lee Jinyoung Hur Ho-Young Park Ho-Young Park Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model Frontiers in Nutrition Acorus gramineus polysaccharides metabolic dysfunction-associated steatotic liver disease metabolic endotoxemia prebiotic |
| title | Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model |
| title_full | Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model |
| title_fullStr | Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model |
| title_full_unstemmed | Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model |
| title_short | Prebiotic potential and metabolic benefits of Acorus gramineus rhizome-derived polysaccharides in a high-fat diet-induced obesity model |
| title_sort | prebiotic potential and metabolic benefits of acorus gramineus rhizome derived polysaccharides in a high fat diet induced obesity model |
| topic | Acorus gramineus polysaccharides metabolic dysfunction-associated steatotic liver disease metabolic endotoxemia prebiotic |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1605201/full |
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