Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season
Abstract Background Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur....
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s41182-025-00688-7 |
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| author | Htin Lin Mya Myat Ngwe Tun Yin Mon Wint Zin Khin Theingi Myint Win Kay Khine Khine Mya Nwe Aye Aye Thant Thin Thin Shwe Win Mar Khin Sandar Aye Khaing Moe Aung Yuki Takamatsu Wah Wah Aung Yi Yi Kyaw Takeshi Urano Kouichi Morita Hlaing Myat Thu |
| author_facet | Htin Lin Mya Myat Ngwe Tun Yin Mon Wint Zin Khin Theingi Myint Win Kay Khine Khine Mya Nwe Aye Aye Thant Thin Thin Shwe Win Mar Khin Sandar Aye Khaing Moe Aung Yuki Takamatsu Wah Wah Aung Yi Yi Kyaw Takeshi Urano Kouichi Morita Hlaing Myat Thu |
| author_sort | Htin Lin |
| collection | DOAJ |
| description | Abstract Background Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur. Adults are more likely than children to experience co-infections of dengue and other diseases. Although pediatric dengue has been studied in Yangon for decades, research on adult dengue is scant. Therefore, this study compared the clinical and virological characteristics of pediatric and adult dengue cases in Yangon. Methods This cross-sectional study was conducted at Insein General Hospital in Yangon, Myanmar, from June to September 2022. We recruited 221 suspected dengue patients (134 children and 87 adults), with or without other diseases, and tested their dengue serological markers using a serological method and their dengue virus (DENV) serotypes using conventional RT-PCR. Chi-squared and Fisher’s exact tests were conducted to assess significance. Results The dengue non-structural protein-1 antigen (NS1Ag) positivity was 37% in children and 32% in adults. DENV serotypes were identified in 80% of NS1Ag-positive patients. Among NS1Ag-positive cases, the DENV-1 serotype predominated (67%), followed by DENV-2 (17%), DENV-3 (9%), DENV-4 (5%), and mixed DENV-1 and DENV-2 (2%) serotypes. Shock was observed in 14% of children and 3% of adults. Anti-dengue IgG antibody positivity was positively correlated with dengue shock. Three pediatric dengue cases (6%) also had other infections including bronchiolitis, ear infection, and diarrhea. Seven adult dengue cases (25%) also had other diseases including advanced HIV infection, severe pneumonia, tonsillitis, thyroid disease, cholecystitis, drug poisoning, and thalassemia. Conclusion The serotype distribution and clinical presentations of pediatric and adult dengue cases were not significantly different, but adults were more likely to have dengue together with other diseases than children. This study provides information for the better management of febrile children and adults in hospital settings and provides a foundation for nationwide epidemiological studies on dengue serotypes and modifications of the national guidelines for dengue management in Myanmar. |
| format | Article |
| id | doaj-art-70a500fb023742329026292c535ee92e |
| institution | Kabale University |
| issn | 1349-4147 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Tropical Medicine and Health |
| spelling | doaj-art-70a500fb023742329026292c535ee92e2025-02-02T12:43:11ZengBMCTropical Medicine and Health1349-41472025-01-0153111010.1186/s41182-025-00688-7Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue seasonHtin Lin0Mya Myat Ngwe Tun1Yin Mon Wint Zin2Khin Theingi Myint3Win Kay Khine4Khine Mya Nwe5Aye Aye Thant6Thin Thin Shwe7Win Mar8Khin Sandar Aye9Khaing Moe Aung10Yuki Takamatsu11Wah Wah Aung12Yi Yi Kyaw13Takeshi Urano14Kouichi Morita15Hlaing Myat Thu16Department of Medical Research, Ministry of HealthDepartment of Virology, Institute of Tropical Medicine, Nagasaki UniversityInsein Teaching and General HospitalInsein Teaching and General HospitalDepartment of Medical Research, Ministry of HealthDepartment of Virology, Institute of Tropical Medicine, Nagasaki UniversityInsein Teaching and General HospitalDepartment of Medical Research, Ministry of HealthDepartment of Medical Research, Ministry of HealthDepartment of Medical Research, Ministry of HealthDepartment of Medical Research, Ministry of HealthDepartment of Virology, Institute of Tropical Medicine, Nagasaki UniversityDepartment of Medical Research, Ministry of HealthDepartment of Medical Research, Ministry of HealthDepartment of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki UniversityDepartment of Virology, Institute of Tropical Medicine, Nagasaki UniversityDepartment of Medical Research, Ministry of HealthAbstract Background Myanmar is one of the countries in Southeast Asia where serious dengue outbreaks occur and Yangon is among the regions with the highest number of cases in the country. Many infections including dengue are common in Yangon during the rainy season, and co-infections may also occur. Adults are more likely than children to experience co-infections of dengue and other diseases. Although pediatric dengue has been studied in Yangon for decades, research on adult dengue is scant. Therefore, this study compared the clinical and virological characteristics of pediatric and adult dengue cases in Yangon. Methods This cross-sectional study was conducted at Insein General Hospital in Yangon, Myanmar, from June to September 2022. We recruited 221 suspected dengue patients (134 children and 87 adults), with or without other diseases, and tested their dengue serological markers using a serological method and their dengue virus (DENV) serotypes using conventional RT-PCR. Chi-squared and Fisher’s exact tests were conducted to assess significance. Results The dengue non-structural protein-1 antigen (NS1Ag) positivity was 37% in children and 32% in adults. DENV serotypes were identified in 80% of NS1Ag-positive patients. Among NS1Ag-positive cases, the DENV-1 serotype predominated (67%), followed by DENV-2 (17%), DENV-3 (9%), DENV-4 (5%), and mixed DENV-1 and DENV-2 (2%) serotypes. Shock was observed in 14% of children and 3% of adults. Anti-dengue IgG antibody positivity was positively correlated with dengue shock. Three pediatric dengue cases (6%) also had other infections including bronchiolitis, ear infection, and diarrhea. Seven adult dengue cases (25%) also had other diseases including advanced HIV infection, severe pneumonia, tonsillitis, thyroid disease, cholecystitis, drug poisoning, and thalassemia. Conclusion The serotype distribution and clinical presentations of pediatric and adult dengue cases were not significantly different, but adults were more likely to have dengue together with other diseases than children. This study provides information for the better management of febrile children and adults in hospital settings and provides a foundation for nationwide epidemiological studies on dengue serotypes and modifications of the national guidelines for dengue management in Myanmar.https://doi.org/10.1186/s41182-025-00688-7DengueSerotypeMyanmarChildrenAdult |
| spellingShingle | Htin Lin Mya Myat Ngwe Tun Yin Mon Wint Zin Khin Theingi Myint Win Kay Khine Khine Mya Nwe Aye Aye Thant Thin Thin Shwe Win Mar Khin Sandar Aye Khaing Moe Aung Yuki Takamatsu Wah Wah Aung Yi Yi Kyaw Takeshi Urano Kouichi Morita Hlaing Myat Thu Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season Tropical Medicine and Health Dengue Serotype Myanmar Children Adult |
| title | Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season |
| title_full | Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season |
| title_fullStr | Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season |
| title_full_unstemmed | Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season |
| title_short | Comparison of clinical and virological features in pediatric and adult dengue cases at Insein General Hospital during Myanmar’s 2022 dengue season |
| title_sort | comparison of clinical and virological features in pediatric and adult dengue cases at insein general hospital during myanmar s 2022 dengue season |
| topic | Dengue Serotype Myanmar Children Adult |
| url | https://doi.org/10.1186/s41182-025-00688-7 |
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