Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children
<b>Background/Objectives</b>: The Tc-99m dimercaptosuccinic acid (DMSA) renal scan clearly images the renal cortex, highlighting functional tissue areas and indicating regions of renal scarring, infection, malformations, or other types of renal damage. To enhance the management of paedia...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2075-4418/15/8/1025 |
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| author | Irena Cristina Grierosu Iuliana Magdalena Starcea Wael Jalloul Maria Adriana Mocanu Roxana Alexandra Bogos Tudor Ilie Lazaruc Madalina Andreea Beldie Ruxandra Tibu Teodor Marian Ionescu Cati Raluca Stolniceanu Brindusa Casiana Acsinte Cipriana Stefanescu Alexandra Saviuc Vlad Ghizdovat |
| author_facet | Irena Cristina Grierosu Iuliana Magdalena Starcea Wael Jalloul Maria Adriana Mocanu Roxana Alexandra Bogos Tudor Ilie Lazaruc Madalina Andreea Beldie Ruxandra Tibu Teodor Marian Ionescu Cati Raluca Stolniceanu Brindusa Casiana Acsinte Cipriana Stefanescu Alexandra Saviuc Vlad Ghizdovat |
| author_sort | Irena Cristina Grierosu |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: The Tc-99m dimercaptosuccinic acid (DMSA) renal scan clearly images the renal cortex, highlighting functional tissue areas and indicating regions of renal scarring, infection, malformations, or other types of renal damage. To enhance the management of paediatric cases involving renal malformations and to reduce the incidence of chronic and progressive kidney diseases in “future adults”, our study aims to identify and categorise various renal anomalies. <b>Methods</b>: This has been achieved by analysing the Tc-99m DMSA renal scans of a large cohort of 931 children diagnosed with different renal pathologies. After interpreting the scans, we categorised the renal malformations and cortical modifications into four groups: kidney number anomalies, positional anomalies, structural anomalies, and shape anomalies. <b>Results</b>: There has been a notable increase in the demand for renal scintigraphy in recent years, rising from 82 cases in 2019 to 183 cases in 2024. Structural anomalies were the most common type of malformations (73% from all patients), featuring a significant variety of cortical modifications. In total, 98 cases (93% from kidney number anomalies and 10.5% from all children) were diagnosed with renal agenesis. Additionally, 30 children (3.2% from all patients) had positional anomalies, primarily ectopic kidneys, and 54 patients (5.8% from all cases) had shape malformations, especially fused kidneys. <b>Conclusions</b>: Combining the Tc-99m DMSA renal scan with ultrasound provides a more reliable diagnosis of paediatric renal progressive diseases. A more accurate diagnosis allows for quicker treatment and prevention of potential complications, ultimately improving the quality of life and decreasing hospital costs of paediatric patients becoming adults. |
| format | Article |
| id | doaj-art-70a0212e1c1744638b6004aa60d3d0cc |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-70a0212e1c1744638b6004aa60d3d0cc2025-08-20T03:13:51ZengMDPI AGDiagnostics2075-44182025-04-01158102510.3390/diagnostics15081025Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 ChildrenIrena Cristina Grierosu0Iuliana Magdalena Starcea1Wael Jalloul2Maria Adriana Mocanu3Roxana Alexandra Bogos4Tudor Ilie Lazaruc5Madalina Andreea Beldie6Ruxandra Tibu7Teodor Marian Ionescu8Cati Raluca Stolniceanu9Brindusa Casiana Acsinte10Cipriana Stefanescu11Alexandra Saviuc12Vlad Ghizdovat13Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaNuclear Medicine Laboratory, “St. Spiridon” County Emergency Hospital, 700111 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<b>Background/Objectives</b>: The Tc-99m dimercaptosuccinic acid (DMSA) renal scan clearly images the renal cortex, highlighting functional tissue areas and indicating regions of renal scarring, infection, malformations, or other types of renal damage. To enhance the management of paediatric cases involving renal malformations and to reduce the incidence of chronic and progressive kidney diseases in “future adults”, our study aims to identify and categorise various renal anomalies. <b>Methods</b>: This has been achieved by analysing the Tc-99m DMSA renal scans of a large cohort of 931 children diagnosed with different renal pathologies. After interpreting the scans, we categorised the renal malformations and cortical modifications into four groups: kidney number anomalies, positional anomalies, structural anomalies, and shape anomalies. <b>Results</b>: There has been a notable increase in the demand for renal scintigraphy in recent years, rising from 82 cases in 2019 to 183 cases in 2024. Structural anomalies were the most common type of malformations (73% from all patients), featuring a significant variety of cortical modifications. In total, 98 cases (93% from kidney number anomalies and 10.5% from all children) were diagnosed with renal agenesis. Additionally, 30 children (3.2% from all patients) had positional anomalies, primarily ectopic kidneys, and 54 patients (5.8% from all cases) had shape malformations, especially fused kidneys. <b>Conclusions</b>: Combining the Tc-99m DMSA renal scan with ultrasound provides a more reliable diagnosis of paediatric renal progressive diseases. A more accurate diagnosis allows for quicker treatment and prevention of potential complications, ultimately improving the quality of life and decreasing hospital costs of paediatric patients becoming adults.https://www.mdpi.com/2075-4418/15/8/1025Tc-99m DMSA scanpaediatric renal malformationsdifferential renal functionchronic renal failure |
| spellingShingle | Irena Cristina Grierosu Iuliana Magdalena Starcea Wael Jalloul Maria Adriana Mocanu Roxana Alexandra Bogos Tudor Ilie Lazaruc Madalina Andreea Beldie Ruxandra Tibu Teodor Marian Ionescu Cati Raluca Stolniceanu Brindusa Casiana Acsinte Cipriana Stefanescu Alexandra Saviuc Vlad Ghizdovat Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children Diagnostics Tc-99m DMSA scan paediatric renal malformations differential renal function chronic renal failure |
| title | Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children |
| title_full | Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children |
| title_fullStr | Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children |
| title_full_unstemmed | Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children |
| title_short | Particularities in the “Oldie but Goldie” Tc-99m DMSA Renography: A Retrospective Reference Centre Overview of 931 Children |
| title_sort | particularities in the oldie but goldie tc 99m dmsa renography a retrospective reference centre overview of 931 children |
| topic | Tc-99m DMSA scan paediatric renal malformations differential renal function chronic renal failure |
| url | https://www.mdpi.com/2075-4418/15/8/1025 |
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