miRNAs: The Key Regulator of COVID-19 Disease
As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2022/1645366 |
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| _version_ | 1849413781841510400 |
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| author | Leyla Tahrani Hardin Nan Xiao |
| author_facet | Leyla Tahrani Hardin Nan Xiao |
| author_sort | Leyla Tahrani Hardin |
| collection | DOAJ |
| description | As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody’s neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the “virus intelligence” to escape and antagonize the host miRNAs as well as the possible mechanisms that could be used in the viral evasion strategies are discussed. Lastly, we suggest new therapeutic approaches based on viral miRNAs. |
| format | Article |
| id | doaj-art-709f4753f04440a383e1bf30672d2f7c |
| institution | Kabale University |
| issn | 1687-8884 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-709f4753f04440a383e1bf30672d2f7c2025-08-20T03:34:01ZengWileyInternational Journal of Cell Biology1687-88842022-01-01202210.1155/2022/1645366miRNAs: The Key Regulator of COVID-19 DiseaseLeyla Tahrani Hardin0Nan Xiao1Department of Biomedical Sciences at the Arthur A. Dugoni School of DentistryDepartment of Biomedical Sciences at the Arthur A. Dugoni School of DentistryAs many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody’s neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the “virus intelligence” to escape and antagonize the host miRNAs as well as the possible mechanisms that could be used in the viral evasion strategies are discussed. Lastly, we suggest new therapeutic approaches based on viral miRNAs.http://dx.doi.org/10.1155/2022/1645366 |
| spellingShingle | Leyla Tahrani Hardin Nan Xiao miRNAs: The Key Regulator of COVID-19 Disease International Journal of Cell Biology |
| title | miRNAs: The Key Regulator of COVID-19 Disease |
| title_full | miRNAs: The Key Regulator of COVID-19 Disease |
| title_fullStr | miRNAs: The Key Regulator of COVID-19 Disease |
| title_full_unstemmed | miRNAs: The Key Regulator of COVID-19 Disease |
| title_short | miRNAs: The Key Regulator of COVID-19 Disease |
| title_sort | mirnas the key regulator of covid 19 disease |
| url | http://dx.doi.org/10.1155/2022/1645366 |
| work_keys_str_mv | AT leylatahranihardin mirnasthekeyregulatorofcovid19disease AT nanxiao mirnasthekeyregulatorofcovid19disease |