HMOX1 as a Novel Biomarker for Glucose–Lipid Metabolism Disorder and T2DM: Systematic Bioinformatics Investigation and Experimental Verification

HMOX1 as a Novel Biomarker for Glucose–Lipid Metabolism Disorder and T2DM: Systematic Bioinformatics Investigation and Experimental Verification

Saved in:

Bibliographic Details
Main Authors:	Qi Xu, Hongrong Zhang, Nuobing Ruan, Jiawen Jing, Yufan Li, Jindong Zhao, Zhaohui Fang
Format:	Article
Language:	English
Published:	American Chemical Society 2025-04-01
Series:	ACS Omega
Online Access:	https://doi.org/10.1021/acsomega.4c09662
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Mediating effect of TyG index on the association between glucose-lipid metabolism-related dietary pattern and T2DM: a propensity score-matched analysis
by: ShuShu Li, et al.
Published: (2025-04-01)

Identification of Key Nucleotide Metabolism Genes in Diabetic Retinopathy Based on Bioinformatics Analysis and Experimental Verification
by: Wei Wang, et al.
Published: (2025-04-01)

Unveiling the molecular mechanisms of stigmasterol on diabetic retinopathy: BNM framework construction and experimental validation
by: Hongrong Zhang, et al.
Published: (2025-05-01)

Potential diagnostic markers and therapeutic targets for DM2 and periodontitis based on bioinformatics analysis.
by: Rong Luo, et al.
Published: (2025-01-01)

Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences
by: Kalaiyarasi Vasuthas, et al.
Published: (2025-10-01)

Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics
by: Xun Huang, et al.
Published: (2025-03-01)

Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression
by: Chengcheng Zhao, et al.
Published: (2025-08-01)

Metformin effects to carbohydrate and lipids metabolism in impaired glucose tolerance patients.
by: Alexander Vasil'evich Dreval', et al.
Published: (2010-06-01)

The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes
by: Yinjie Gao, et al.
Published: (2021-01-01)

Efficacy of paleolithic diet in control of blood glucose level in type 2 DM patients
by: Nagy Nageh Abdo Sous, et al.
Published: (2025-08-01)

The role of Triglyceride-Glucose index in predicting pre-DM risk among Chinese adults
by: Zhangxin Wen, et al.
Published: (2025-07-01)

Comprehensive bioinformatics analysis and experimental verification identify mitochondrial gene Dgat2 as a novel therapeutic biomarker for myocardial ischemia-reperfusion
by: Hong Li, et al.
Published: (2025-05-01)

Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota–Bile Acid Axis
by: Jin Jiang, et al.
Published: (2025-07-01)

The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium
by: Chunyi Ji, et al.
Published: (2025-05-01)

Sesamin protects against Acetaminophen-induced nephrotoxicity by suppressing HMOX1-mediated apoptosis and ferroptosis
by: Siqi Zhu, et al.
Published: (2025-12-01)

Bioinformatics analysis of shared biomarkers and immune pathways of preeclampsia and periodontitis
by: Fangyi Ruan, et al.
Published: (2025-02-01)

CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD
by: Xinru Jiang, et al.
Published: (2025-06-01)

Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics
by: Qiang S, et al.
Published: (2025-07-01)

DEVELOPMENT OF "KERR EFFECT" DEVICES TO MEASURE URINE GLUCOSE LEVELS OF DIABETES MELITUS (DM) PATIENTS
by: Nurun Nayiroh, et al.
Published: (2019-09-01)

Dynamics of lipid and carbohydrate metabolism parameters in women with menopausal metabolic syndrome, receiving glucose-lowering therapy
by: A. V. Starodubova, et al.
Published: (2011-08-01)

Serum Amylase Levels in T2DM Patients: Surrogate Biomarker of Cardiometabolic Status
by: M. Rasheed Khan, et al.
Published: (2025-01-01)

HMOX1 Attenuates the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib via Modulating the Expression of ABC Transporters
by: Xian Zhu, et al.
Published: (2022-01-01)

Identification of Energy Metabolism-Related Subtypes and Diagnostic Biomarkers for Osteoarthritis by Integrating Bioinformatics and Machine Learning
by: Xu S, et al.
Published: (2025-03-01)

Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis
by: Xuyun Xia, et al.
Published: (2025-03-01)

Exploring the role of lipid metabolism related genes and immune microenvironment in periodontitis by integrating machine learning and bioinformatics analysis
by: Lulu Wei, et al.
Published: (2025-08-01)

Effects of Ellagic Acid on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis
by: Xuelian Wang, et al.
Published: (2024-01-01)

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.
by: Michael Walther, et al.
Published: (2012-01-01)

Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies
by: Yan An, et al.
Published: (2025-05-01)

Comprehensive bioinformatics and immunohistochemical analyses identify phosphoinositide metabolism and PNPLA7 as potential biomarkers in urological cancers
by: Yinhao Chen, et al.
Published: (2025-04-01)

Bioinformatics analysis combined with untargeted metabolomics reveals lipid metabolism-related genes and their biological markers in chronic spontaneous urticaria
by: Zhiming Hu, et al.
Published: (2025-08-01)

Identification and analysis of neutrophil extracellular trap-related genes in periodontitis via bioinformatics and experimental verification
by: Miao Yu, et al.
Published: (2025-08-01)

Mechanism of miR-107/HMOX1 axis in hepatic sinusoidal endothelial cells stimulated by ischemia-reperfusion injury
by: Zhao Wang, et al.
Published: (2025-07-01)

Identification of prognostic and therapeutic biomarkers associated with macrophage and lipid metabolism in pancreatic cancer
by: Lili Wu, et al.
Published: (2025-04-01)

Irisin in Type 2 Diabetes and Obesity: A Biomarker of Metabolic and Lipid Dysregulation
by: Sanja Stanković, et al.
Published: (2025-06-01)

Lipid metabolism-related inflammatory indices (LMIIs) and incident peripheral artery diseases (PAD) in patients with type 2 diabetes mellitus (T2DM): a multicohort study from China and the UK biobank
by: Yingying Wang, et al.
Published: (2025-08-01)

Coupling relationship between glucose and oxygen metabolisms to serve as an imaging biomarker for Alzheimer’s disease
by: Ze Yang, et al.
Published: (2025-05-01)

Molecular and clinical profiles of T2DM, dyslipidemia, and periodontitis: insights into inflammatory and metabolic dysregulation
by: Peace Ngozi Okoro, et al.
Published: (2025-05-01)

Glucose and lipid metabolism in non-diabetic, non-obese patients with obstructive sleep apnea: sex differences
by: Yuhan Wang, et al.
Published: (2025-08-01)

Ubiquitous expression of an activating mutation in the Pik3ca gene reprograms glucose and lipid metabolism in mice.
by: Sabrina Caiazzo, et al.
Published: (2025-01-01)

Identification and verification of XDH genes in ROS induced oxidative stress response of osteoarthritis based on bioinformatics analysis
by: Chengze Qiu, et al.
Published: (2025-08-01)