Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues
Hodgkin’s lymphoma (HL) is highly sensitive to chemo- and radiotherapy. Long-term tumor-free survival in patients with early stages is close to 95–98 %. Therapy results in patients with advanced stages is worse that requires an intensification of treatment and creates the issuesof late toxicity prev...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/6 |
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| author | Yu. V. Larina S. V. Minenko E. R. Biyachuev A. V. Pshonkin N. K. Khuazheva V. V. Ptushkin |
| author_facet | Yu. V. Larina S. V. Minenko E. R. Biyachuev A. V. Pshonkin N. K. Khuazheva V. V. Ptushkin |
| author_sort | Yu. V. Larina |
| collection | DOAJ |
| description | Hodgkin’s lymphoma (HL) is highly sensitive to chemo- and radiotherapy. Long-term tumor-free survival in patients with early stages is close to 95–98 %. Therapy results in patients with advanced stages is worse that requires an intensification of treatment and creates the issuesof late toxicity prevention. These problems are especially relevant in young adults with a life expectancy of 40 years or more. Escalated BEACOPP protocol developed by the German study group allows to achieve cure the majority of patients with advanced-stage Hodgkin’s lymphoma, but this regime has significant toxicity. It causes infertility in almost all patients. BEACOPP-14 with comparable activity contains less cumulative doses of potentially gonadotoxic alkylating agents. Efficacy and toxicity of this regime has been analyzed in 29 patients with prognostically unfavorable stages of HL (m – 13, f – 16) received 8 courses BEACOPP-14 without a dose reduction of cytostatics. The median age of patients was 24 (20–35) years. With a median follow-up of 32.8 (4–66) months, event-free survival was 92.8 %, disease-free – 96.2 %, and overall survival – 95.2 %. Of the 16 women included in the study, the menstrual cycle was restored in 14 patients during 3–6 months. 2 patients were not evaluated because of switch to more intensive chemotherapy in the early stages of treatment. Of the remaining 14 patients pregnancy occurred in 3 (18.7 %), delivery – in 2, abortion – in 1. Delivery was term, children born healthy. Most of the patients according to the doctors’ recommendations protects and continues to avoid pregnancy for 2 years after treatment. The data indicate a potentially less reproductive damaging of BEACOPP-14 in females retaining high anti-tumor efficacy. |
| format | Article |
| id | doaj-art-7094ad1cb6ea4faf8d7af8b9687b551e |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-7094ad1cb6ea4faf8d7af8b9687b551e2025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232014-07-0191111810.17650/1818-8346-2014-9-1-11-1821Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issuesYu. V. Larina0S. V. Minenko1E. R. Biyachuev2A. V. Pshonkin3N. K. Khuazheva4V. V. Ptushkin5Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of RussiaS. P. Botkin City Clinical Hospital, Moscow Healthcare DepartmentFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia N. I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaHodgkin’s lymphoma (HL) is highly sensitive to chemo- and radiotherapy. Long-term tumor-free survival in patients with early stages is close to 95–98 %. Therapy results in patients with advanced stages is worse that requires an intensification of treatment and creates the issuesof late toxicity prevention. These problems are especially relevant in young adults with a life expectancy of 40 years or more. Escalated BEACOPP protocol developed by the German study group allows to achieve cure the majority of patients with advanced-stage Hodgkin’s lymphoma, but this regime has significant toxicity. It causes infertility in almost all patients. BEACOPP-14 with comparable activity contains less cumulative doses of potentially gonadotoxic alkylating agents. Efficacy and toxicity of this regime has been analyzed in 29 patients with prognostically unfavorable stages of HL (m – 13, f – 16) received 8 courses BEACOPP-14 without a dose reduction of cytostatics. The median age of patients was 24 (20–35) years. With a median follow-up of 32.8 (4–66) months, event-free survival was 92.8 %, disease-free – 96.2 %, and overall survival – 95.2 %. Of the 16 women included in the study, the menstrual cycle was restored in 14 patients during 3–6 months. 2 patients were not evaluated because of switch to more intensive chemotherapy in the early stages of treatment. Of the remaining 14 patients pregnancy occurred in 3 (18.7 %), delivery – in 2, abortion – in 1. Delivery was term, children born healthy. Most of the patients according to the doctors’ recommendations protects and continues to avoid pregnancy for 2 years after treatment. The data indicate a potentially less reproductive damaging of BEACOPP-14 in females retaining high anti-tumor efficacy.https://oncohematology.abvpress.ru/ongm/article/view/6hodgkin’s lymphomachemotherapytoxicityreproductive functionbeacopp-14 |
| spellingShingle | Yu. V. Larina S. V. Minenko E. R. Biyachuev A. V. Pshonkin N. K. Khuazheva V. V. Ptushkin Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues Онкогематология hodgkin’s lymphoma chemotherapy toxicity reproductive function beacopp-14 |
| title | Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues |
| title_full | Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues |
| title_fullStr | Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues |
| title_full_unstemmed | Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues |
| title_short | Treatment of advanced Hodgkin lymphomas in adolescents and young adults: efficacy and toxicity issues |
| title_sort | treatment of advanced hodgkin lymphomas in adolescents and young adults efficacy and toxicity issues |
| topic | hodgkin’s lymphoma chemotherapy toxicity reproductive function beacopp-14 |
| url | https://oncohematology.abvpress.ru/ongm/article/view/6 |
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