A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine
Measles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable responses for anti-mumps antibodies. Most common...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2302685 |
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| author | Nitin Shah Apurba Ghosh Kishore Kumar Trayambak Dutta Manish Mahajan |
| author_facet | Nitin Shah Apurba Ghosh Kishore Kumar Trayambak Dutta Manish Mahajan |
| author_sort | Nitin Shah |
| collection | DOAJ |
| description | Measles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable responses for anti-mumps antibodies. Most common strains for MMR vaccines, currently available in India, are the Edmonston-Zagreb measles strain, Leningrad Zagreb (L-Z) mumps strain, and the RA 27/3 rubella strain. L-Z strain of mumps virus has been found to be associated with aseptic meningitis by different studies from different parts of the world including India. Recently, a novel freeze-dried MMR vaccine developed by Zydus Lifesciences (Zyvac MMR) contains Edmonston Zagreb measles strain, Hoshino mumps strain, and RA 27/3 rubella strain. The Hoshino strain is WHO approved and was found to induce interferon gamma production. This review article aims to provide a comprehensive appraisal of the data available on the safety and immunogenicity of the novel MMR vaccine. |
| format | Article |
| id | doaj-art-7093428b00aa48bc8099b3038e06a76e |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-7093428b00aa48bc8099b3038e06a76e2025-08-20T03:21:46ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2302685A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccineNitin Shah0Apurba Ghosh1Kishore Kumar2Trayambak Dutta3Manish Mahajan4Department of Peadiatrics, P.D Hinduja Hospital & Medical Research Centre, Mumbai, IndiaDepartment of Peadiatrics, Institute of Child Health, Kolkata, IndiaDepartment of Peadiatrics, CloudNine Group of Hospitals, Bengaluru, IndiaMedical Affairs, Zydus Lifesciences Ltd., Zydus Corporate Park, Ahmedabad, IndiaMedical Affairs, Zydus Lifesciences Ltd., Zydus Corporate Park, Ahmedabad, IndiaMeasles, mumps, and rubella (MMR) are highly infectious viral diseases affecting young children and have high secondary attack rates. Present MMR vaccines show consistent seroconversion rates for anti-measles and anti-rubella antibodies with variable responses for anti-mumps antibodies. Most common strains for MMR vaccines, currently available in India, are the Edmonston-Zagreb measles strain, Leningrad Zagreb (L-Z) mumps strain, and the RA 27/3 rubella strain. L-Z strain of mumps virus has been found to be associated with aseptic meningitis by different studies from different parts of the world including India. Recently, a novel freeze-dried MMR vaccine developed by Zydus Lifesciences (Zyvac MMR) contains Edmonston Zagreb measles strain, Hoshino mumps strain, and RA 27/3 rubella strain. The Hoshino strain is WHO approved and was found to induce interferon gamma production. This review article aims to provide a comprehensive appraisal of the data available on the safety and immunogenicity of the novel MMR vaccine.https://www.tandfonline.com/doi/10.1080/21645515.2024.2302685MMRIndiaHoshinoLeningrad ZagrebIAPaseptic meningitis |
| spellingShingle | Nitin Shah Apurba Ghosh Kishore Kumar Trayambak Dutta Manish Mahajan A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine Human Vaccines & Immunotherapeutics MMR India Hoshino Leningrad Zagreb IAP aseptic meningitis |
| title | A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine |
| title_full | A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine |
| title_fullStr | A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine |
| title_full_unstemmed | A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine |
| title_short | A review of safety and immunogenicity of a novel measles, mumps, rubella (MMR) vaccine |
| title_sort | review of safety and immunogenicity of a novel measles mumps rubella mmr vaccine |
| topic | MMR India Hoshino Leningrad Zagreb IAP aseptic meningitis |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2302685 |
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