Application value of high flux hemodialysis in uremic elders
Objective To explore the application value of high flux hemodialysis（HFHD）in uremic elders.Methods From October 2018 to January 2020,a total of 102 uremic elders aged over 70 years were selected and randomized into two groups of study and control（n=51 each）.On the basis of routine intervention, stud...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2021-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57904733&Fpath=home&index=0 |
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| Summary: | Objective To explore the application value of high flux hemodialysis（HFHD）in uremic elders.Methods From October 2018 to January 2020,a total of 102 uremic elders aged over 70 years were selected and randomized into two groups of study and control（n=51 each）.On the basis of routine intervention, study group received 12-week HFHD while control group had 12-week low flux hemodialysis（LFHD）.Clinical efficacy, blood urea nitrogen（BUN）,serum creatinine（Scr）,p-cresol sulfate（PCS）,indolyl sulfate（IS）and serum creatinine（Scr）of two groups were statistically analyzed.And β2-microglobulin（β2-mg）,parathyroid hormone（PTH）,neutrophil（NE）phagocytic function（phagocytic rate/index）,serum inflammatory factors such as C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）and interleukin-8（IL-8）were measured.The parameters of calcium and phosphorus metabolism, such as serum calcium（CA）and phosphorus（P）,were followed up for 3 months.Results The overall effective rate of study group was higher than that of control group（94.12% vs 80.39%）（P<0.05）.At 6 and 12 weeks of treatment, serum BUN,Scr, PCs, IS, β2-MG,PTH,CRP and TNF-α declined and their levels were lower than controls.The levels of IL-6,IL-8 and P were lower in study group than those in control group（P<0.05）;At 6 and 12 weeks of treatment, NE phagocytosis rate/index of two groups were higher than pre-treatment and study group was higher than control group（P<0.05）;no significant inter-group difference existed in mortality at Month 1/2/3 post-treatment（P>0.05）.Conclusion HFHD technology can effectively improve the therapeutic efficacy for uremic elders.It is probably correlated to a more effective removal of toxins, a modulation of serum inflammatory factors, calcium and phosphorus metabolism and NE phagocytosis. |
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| ISSN: | 1671-2390 |