Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease

Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease

<b>Background:</b> The goal of the current study was to investigate the inhibitory activity of six phenolic compounds, i.e., rosmarinic acid, gallic acid, oleuropein, epigallocatechin gallate (EGCG), 3-hydroxytyrosol, and quercetin, against β-site amyloid precursor protein cleaving enzym...

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Bibliographic Details
Main Authors: Tugba Uçar Akyürek, Ilkay Erdogan Orhan, F. Sezer Şenol Deniz, Gokcen Eren, Busra Acar, Alaattin Sen
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceuticals
Subjects:
Alzheimer’s disease
beta secretase
cytotoxicity
gene expression
molecular docking
neuroprotection
Online Access:https://www.mdpi.com/1424-8247/17/11/1441
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