Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.
Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting a...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-09-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001353&type=printable |
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| _version_ | 1850129713450713088 |
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| author | Daniel Sauter Frank Kirchhoff |
| author_facet | Daniel Sauter Frank Kirchhoff |
| author_sort | Daniel Sauter |
| collection | DOAJ |
| description | Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response. |
| format | Article |
| id | doaj-art-7076294ccbf04b95b0f2fe6213b5c9da |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-7076294ccbf04b95b0f2fe6213b5c9da2025-08-20T02:32:53ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852021-09-01199e300135310.1371/journal.pbio.3001353Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity.Daniel SauterFrank KirchhoffViruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001353&type=printable |
| spellingShingle | Daniel Sauter Frank Kirchhoff Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. PLoS Biology |
| title | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. |
| title_full | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. |
| title_fullStr | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. |
| title_full_unstemmed | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. |
| title_short | Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. |
| title_sort | less is more biased loss of cpg dinucleotides strengthens antiviral immunity |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001353&type=printable |
| work_keys_str_mv | AT danielsauter lessismorebiasedlossofcpgdinucleotidesstrengthensantiviralimmunity AT frankkirchhoff lessismorebiasedlossofcpgdinucleotidesstrengthensantiviralimmunity |