Mitochondrial Translation Inhibition Uncovers a Critical Metabolic–Epigenetic Interface in Renal Cell Carcinoma

Mitochondrial Translation Inhibition Uncovers a Critical Metabolic–Epigenetic Interface in Renal Cell Carcinoma

<b>Background/Objectives:</b> Renal cell carcinoma (RCC) exhibits distinctive metabolic vulnerabilities that may be therapeutically targeted. This study investigates how tigecycline, an FDA-approved antibiotic that inhibits mitochondrial translation, affects RCC cells and explores potent...

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Bibliographic Details
Main Authors: Kazumi Eckenstein, Beyza Cengiz, Matthew E. K. Chang, Jessie May Cartier, Mark R. Flory, George V. Thomas
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
renal cell carcinoma
mitochondria
translation
histones
tigecycline
entinostat
Online Access:https://www.mdpi.com/2218-1989/15/6/393
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