miRNA centered regulatory networks identify FN1 and miR27b as metastatic drivers in HPV negative head and neck cancer

miRNA centered regulatory networks identify FN1 and miR27b as metastatic drivers in HPV negative head and neck cancer

Abstract The metastasis of human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSC) is associated with poor prognosis, yet the regulatory mechanisms remain unclear. In this study, we developed a metastasis prediction model using the transcriptomes of 333 HPV-negative HNSC tu...

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Bibliographic Details
Main Authors: Su Han Cho, MinJeong Kim, Jiyeon Kim, Seok June Hong, Yuseong Lee, Young Chan Lee, Kwoneel Kim
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Human papilloma virus-negative head and neck squamous cell carcinoma
Metastasis-related biomarkers
Regulatory networks
Prediction model
Fibronectin
miRNA-27b
Online Access:https://doi.org/10.1038/s41598-025-08646-3
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