When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus
Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnos...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2017-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/8824 |
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| author | Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova |
| author_facet | Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova |
| author_sort | Elena V. Buryukova |
| collection | DOAJ |
| description | Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnosed, untreated, or inadequately treated diabetes, emphasizing the need for better clinical management. The introduction of basal insulin therapy is often necessary for patients with T2DM when oral antihyperglycemic drugs and lifestyle management strategies are no longer effective inmaintaining glycemic targets. However, after initiation of insulin, patients often remain on basal insulin for long periods despite suboptimal glycemic control, and intensification of insulin therapy is frequently necessary. Here, we report on several different insulin intensification strategies available to clinicians and their patients to improve glycemic control and the advantages and disadvantages of each approach. These strategies include the use of short- and long-acting insulins administered either as bolus doses or as premixed insulins. When selecting the most appropriate intensification strategy, clinicians should consider the lifestyle and treatment goals of their patients to help ensure treatment success. |
| format | Article |
| id | doaj-art-7064630c00a648cdb4fccd13437a7832 |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-7064630c00a648cdb4fccd13437a78322025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782017-12-0120536337310.14341/DM88248349When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitusElena V. Buryukova0Abdul Jabbar1Svetlana V. Elizarova2<p>Moscow state medical dental University named A. I. Evdokimov</p><p>Eli Lilly and Company</p><p>Lilly Pharma Ltd</p>Maintaining glycemic control through intensive clinical management of patients with type 2 diabetes mellitus (T2DM) is well recognized to reduce the risk of diabetes-associated complications. Patients in Russia have high rates of microvascular and macrovascular complications as a result of undiagnosed, untreated, or inadequately treated diabetes, emphasizing the need for better clinical management. The introduction of basal insulin therapy is often necessary for patients with T2DM when oral antihyperglycemic drugs and lifestyle management strategies are no longer effective inmaintaining glycemic targets. However, after initiation of insulin, patients often remain on basal insulin for long periods despite suboptimal glycemic control, and intensification of insulin therapy is frequently necessary. Here, we report on several different insulin intensification strategies available to clinicians and their patients to improve glycemic control and the advantages and disadvantages of each approach. These strategies include the use of short- and long-acting insulins administered either as bolus doses or as premixed insulins. When selecting the most appropriate intensification strategy, clinicians should consider the lifestyle and treatment goals of their patients to help ensure treatment success.https://www.dia-endojournals.ru/jour/article/view/8824diabetes mellitus, type 2insulininsulin mixturesinsulin intensificationhemoglobin aglycosylatedefficacysafety |
| spellingShingle | Elena V. Buryukova Abdul Jabbar Svetlana V. Elizarova When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus Сахарный диабет diabetes mellitus, type 2 insulin insulin mixtures insulin intensification hemoglobin a glycosylated efficacy safety |
| title | When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| title_full | When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| title_fullStr | When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| title_full_unstemmed | When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| title_short | When basal insulin is not enough: successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| title_sort | when basal insulin is not enough successful strategies for insulin intensification in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus, type 2 insulin insulin mixtures insulin intensification hemoglobin a glycosylated efficacy safety |
| url | https://www.dia-endojournals.ru/jour/article/view/8824 |
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