Associations between asthma and Life’s Essential 8: a cross-sectional study
BackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear. We hypothesize...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1446900/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823858554549829632 |
|---|---|
| author | Jiao Xu Jianlei Tang |
| author_facet | Jiao Xu Jianlei Tang |
| author_sort | Jiao Xu |
| collection | DOAJ |
| description | BackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear. We hypothesized that LE8 is a protective factor against asthma.Materials and methodsMultiple logistic regression analysis, restricted cubic spline (RCS) analysis, and subgroup analysis were used to analyze the data collected from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018.ResultsA total of 3,360 participants with asthma were included in the analysis. With all confounders controlled for, LE8 scores were negatively correlated with asthma prevalence (odds ratio (OR) per 10-point increment, 0.85 [95% confidence interval (CI), 0.82–0.88]). Compared to low LE8 scores, moderate and high LE8 scores were associated with reduced asthma risk, with adjusted ORs (95% CIs) of 0.59 (0.51–0.68) and 0.48 (0.39–0.58), respectively. Non-linear correlations were observed between LE8 scores and asthma (p non-linear = 0.01) and between health factor scores and asthma (p non-linear = 0.01). However, a linear dose–response correlation was noted between health behavior scores and asthma (p non-linear = 0.30). Subgroup analysis showed no significant interaction effects (p > 0.05), except in the sex and drinking status subgroups (p for interaction = 0.02).ConclusionAsthma is associated with components of LE8, which warrants further attention and may contribute to reducing asthma prevalence. |
| format | Article |
| id | doaj-art-7063e2c755e94158a78f5b5cc6fa099b |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-7063e2c755e94158a78f5b5cc6fa099b2025-02-11T11:01:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14469001446900Associations between asthma and Life’s Essential 8: a cross-sectional studyJiao Xu0Jianlei Tang1Department of Respiratory and Critical Care Medicine, WuJin Hospital Affiliated with Jiangsu University, WuJin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaRehabilitation Department, WuJin Hospital Affiliated with Jiangsu University, WuJin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaBackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear. We hypothesized that LE8 is a protective factor against asthma.Materials and methodsMultiple logistic regression analysis, restricted cubic spline (RCS) analysis, and subgroup analysis were used to analyze the data collected from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018.ResultsA total of 3,360 participants with asthma were included in the analysis. With all confounders controlled for, LE8 scores were negatively correlated with asthma prevalence (odds ratio (OR) per 10-point increment, 0.85 [95% confidence interval (CI), 0.82–0.88]). Compared to low LE8 scores, moderate and high LE8 scores were associated with reduced asthma risk, with adjusted ORs (95% CIs) of 0.59 (0.51–0.68) and 0.48 (0.39–0.58), respectively. Non-linear correlations were observed between LE8 scores and asthma (p non-linear = 0.01) and between health factor scores and asthma (p non-linear = 0.01). However, a linear dose–response correlation was noted between health behavior scores and asthma (p non-linear = 0.30). Subgroup analysis showed no significant interaction effects (p > 0.05), except in the sex and drinking status subgroups (p for interaction = 0.02).ConclusionAsthma is associated with components of LE8, which warrants further attention and may contribute to reducing asthma prevalence.https://www.frontiersin.org/articles/10.3389/fmed.2025.1446900/fullLife’s Essential 8asthmahealth behaviors scorehealth factors scoreodd ratios |
| spellingShingle | Jiao Xu Jianlei Tang Associations between asthma and Life’s Essential 8: a cross-sectional study Frontiers in Medicine Life’s Essential 8 asthma health behaviors score health factors score odd ratios |
| title | Associations between asthma and Life’s Essential 8: a cross-sectional study |
| title_full | Associations between asthma and Life’s Essential 8: a cross-sectional study |
| title_fullStr | Associations between asthma and Life’s Essential 8: a cross-sectional study |
| title_full_unstemmed | Associations between asthma and Life’s Essential 8: a cross-sectional study |
| title_short | Associations between asthma and Life’s Essential 8: a cross-sectional study |
| title_sort | associations between asthma and life s essential 8 a cross sectional study |
| topic | Life’s Essential 8 asthma health behaviors score health factors score odd ratios |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1446900/full |
| work_keys_str_mv | AT jiaoxu associationsbetweenasthmaandlifesessential8acrosssectionalstudy AT jianleitang associationsbetweenasthmaandlifesessential8acrosssectionalstudy |