Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis

Summary: AMBRA1, which was initially reported to be essential for nervous system development via autophagy and cell proliferation control, also functions as a tumor suppressor by regulating the ubiquitination of D-type cyclins through interaction with DDB1-Cullin4A/4 B E3 ligase. We had identified a...

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Main Authors: Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki, Norio Yamamoto, Katsuto Hozumi, Tomoaki Tanaka, Hirofumi Nakaoka, Kazuyoshi Hosomichi, Yu Hamaguchi, Michiaki Hamada, Yoshiki Shiraishi, Akihide Kamiya, Yoshihiko Nakamura, Kaito Harada, Abd Aziz Ibrahim, Takashi Yahata, Masato Ohtsuka, Naoya Nakamura, Hiroyuki Hosokawa, Minoru Kimura, Ituro Inoue, Takehito Sato
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501315X
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