Protective Effect of Commercial Grade Vitamin C against Alcohol-induced Testicular Damage in Male Wistar Rats
Background: Alcohol consumption has a negative effect on male fertility, but Vitamin C may be able to alleviate this effect. Aims: In this study, the protective effect of Vitamin C against alcohol-induced testicular damage in adult male Wistar rats was evaluated. Settings and Design: This study was...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-04-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jhrs.jhrs_39_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background:
Alcohol consumption has a negative effect on male fertility, but Vitamin C may be able to alleviate this effect.
Aims:
In this study, the protective effect of Vitamin C against alcohol-induced testicular damage in adult male Wistar rats was evaluated.
Settings and Design:
This study was conducted in a University setting. Following a 14-day acclimatisation period, forty adult male Wistar rats were randomly divided into eight groups of five rats. The control group received only food and water, test group B received alcohol only, test group C to E received different doses of Vitamin C, test group F to G received different doses of Vitamin C and alcohol.
Materials and Methods:
After a 21-day treatment period, the testis were harvested and analysed for sperm parameters, antioxidant enzyme activity, level of lipid peroxidation and histopathological changes.
Statistical Analysis Used:
All analyses was performed using SPSS (version 16) and Microsoft Excel (2019) using Student's t-test.
Results:
The results showed that in groups administered with alcohol only, there was a decrease in sperm count. Sperm motility, morphology, viability and antioxidant enzyme activity, but increase in the level of lipid peroxidation. In groups treated with Vitamin C and alcohol, there was improvement in the sperm parameters, antioxidant enzymes activity and a decrease and decrease in lipid peroxidation. Furthermore, in the histology of the testis, regenerative changes were seen.
Conclusion:
The chronic consumption of alcohol can have a deleterious effect on the testis, but commercial-grade Vitamin C can reverse these effects. |
|---|---|
| ISSN: | 0974-1208 1998-4766 |