A Cross-Sectional Study of Structural and Functional Assessment in Early and Moderate Cases of Primary Open-Angle Glaucoma
Aim: To assess and compare the structural and functional changes in early and moderate cases of primary open-angle glaucoma (POAG). Materials and Methods: An observational, cross-sectional study was done on patients with POAG presenting to a tertiary eye center in Northern India. The structural asse...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/DLJO.DLJO_136_23 |
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| Summary: | Aim:
To assess and compare the structural and functional changes in early and moderate cases of primary open-angle glaucoma (POAG).
Materials and Methods:
An observational, cross-sectional study was done on patients with POAG presenting to a tertiary eye center in Northern India. The structural assessment was based on peripapillary retinal nerve fibre layer (RNFL) thickness which was measured using spectral domain optical coherence tomography (SD-OCT) and functional assessment was visual field (VF) assessment which was done using the Humphrey Field analyzer model 740i. Patients were divided into groups according to Hodapp, Parrish, and Anderson’s criteria.
Results:
Fifty eyes (26 patients) with POAG were included in the study. There were 26 (52%) right eyes and 24 (48%) left eyes. Patients’ average age in the early group was 50.90 ± 6.14 years and the moderate group was 54.40 ± 7.51 years. The RNFL thickness was compared among early and moderate cases of POAG. In early cases, RNFL thickness was found to be 106.33 ± 7.09, and in moderate cases, it was 78.93 ± 26.2. The VF indices were compared among early and moderate cases. In early glaucoma, the mean deviation (MD) was found to be −2.82 ± 0.73, and in moderate glaucoma, it was found to be −11.49 ± 8.26. This correlation between structural and functional changes was found to be statistically significant for superior, inferior, average RNFL thickness, and VF MD. Nasal and temporal RNFL and MD were moderately correlated.
Conclusion:
In our study, we correlated RNFL thickness with VF indices. This correlation between structural and functional changes was found to be statistically significant for superior, inferior, average RNFL thickness, and VF indices. Hence, optical coherence tomography seemed to identify RNFL alterations in early glaucoma even when the VFs and disc appear normal. |
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| ISSN: | 0972-0200 2454-2784 |