Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure
Background/Aim. Glaucoma is a progressive optic neuropathy characterized by damage of the retinal ganglion cells and their axons and glial cells. The aim of this study was to evaluate the differences and connections between changes in the visual field and the thickness of the peripapillary...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600068T.pdf |
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| author | Trenkić-Božinović Marija Zlatanović Gordana Jovanović Predrag Veselinović Dragan Đorđević-Jocić Jasmina Radenković Marija Resan Mirko |
| author_facet | Trenkić-Božinović Marija Zlatanović Gordana Jovanović Predrag Veselinović Dragan Đorđević-Jocić Jasmina Radenković Marija Resan Mirko |
| author_sort | Trenkić-Božinović Marija |
| collection | DOAJ |
| description | Background/Aim. Glaucoma is a progressive optic neuropathy characterized by
damage of the retinal ganglion cells and their axons and glial cells. The
aim of this study was to evaluate the differences and connections between
changes in the visual field and the thickness of the peripapillary retinal
nerve fiber layer (RNFL), using optical coherence tomography (OCT) in
patients with primary open-angle glaucoma with normal and elevated
intraocular pressure (IOP). Methods. This prospective study included 38
patients (38 eyes) with primary open-angle glaucoma with normal intraocular
pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma
with elevated intraocular pressure (HTG), paired by the same degree of
structural glaucomatous changes in the optic nerve head and by age. OCT
protocols ’fast RNFL thickness’ and ’fast optic disc’ were used for testing.
The patients’ age, gender, best corrected visual acuity (BCVA), IOP,
stereometric and functional parameters were compared. Results. The average
age of the examined population was 65.49 ± 9.36 (range 44-83) years. There
was no statistically significant difference by age and by gender between the
two study groups (p = 0.795 and p = 0.807, respectively). BCVA was higher in
patients with NTG but there was no statistically significant difference
compared to HTG patients (p = 0.160). IOP was statistically significantly
higher in patients with HTG compared to NTG patients (17.40 ± 2.77 mmHg vs
14.95 ± 3.01 mmHg, p = 0.009). The cup/disc (C/D) (p = 0.258), mean
deviation (MD) (p = 0.477), corrected patern standard deviation (CPSD) (p =
0.943), disk area (p = 0.515), rim area (p = 0.294), rim volume (p = 0.118),
C/D area R (p = 0.103), RNFL Average (p = 0.632), RNFL Superior (p = 0.283)
and RNFL Inferior (p = 0.488) were not statistically significantly different
between the groups. Conclusion. OCT measurements of the RNFL thickness
provide clinically significant information in monitoring of glaucomatous
changes. There are no differences in the patterns of RNFL defects per
sectors and quadrants between NTG and HTG, measured by OCT. |
| format | Article |
| id | doaj-art-7049c2996f8a4ae29a4fb7f0dac9b06c |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-7049c2996f8a4ae29a4fb7f0dac9b06c2025-08-20T01:57:40ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202016-01-0173761862510.2298/VSP150218068T0042-84501600068TOptical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressureTrenkić-Božinović Marija0Zlatanović Gordana1Jovanović Predrag2Veselinović Dragan3Đorđević-Jocić Jasmina4Radenković Marija5Resan Mirko6University Medical Center Niš, Ophthalmology Clinic, NišUniversity Medical Center Niš, Ophthalmology Clinic, Niš + Faculty of Medicine, NišUniversity Medical Center Niš, Ophthalmology Clinic, Niš + Faculty of Medicine, NišUniversity Medical Center Niš, Ophthalmology Clinic, Niš + Faculty of Medicine, NišUniversity Medical Center Niš, Ophthalmology Clinic, Niš + Faculty of Medicine, NišUniversity Medical Center Niš, Ophthalmology Clinic, NišMilitary Medical Academy, Ophthalmology Clinic, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeBackground/Aim. Glaucoma is a progressive optic neuropathy characterized by damage of the retinal ganglion cells and their axons and glial cells. The aim of this study was to evaluate the differences and connections between changes in the visual field and the thickness of the peripapillary retinal nerve fiber layer (RNFL), using optical coherence tomography (OCT) in patients with primary open-angle glaucoma with normal and elevated intraocular pressure (IOP). Methods. This prospective study included 38 patients (38 eyes) with primary open-angle glaucoma with normal intraocular pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma with elevated intraocular pressure (HTG), paired by the same degree of structural glaucomatous changes in the optic nerve head and by age. OCT protocols ’fast RNFL thickness’ and ’fast optic disc’ were used for testing. The patients’ age, gender, best corrected visual acuity (BCVA), IOP, stereometric and functional parameters were compared. Results. The average age of the examined population was 65.49 ± 9.36 (range 44-83) years. There was no statistically significant difference by age and by gender between the two study groups (p = 0.795 and p = 0.807, respectively). BCVA was higher in patients with NTG but there was no statistically significant difference compared to HTG patients (p = 0.160). IOP was statistically significantly higher in patients with HTG compared to NTG patients (17.40 ± 2.77 mmHg vs 14.95 ± 3.01 mmHg, p = 0.009). The cup/disc (C/D) (p = 0.258), mean deviation (MD) (p = 0.477), corrected patern standard deviation (CPSD) (p = 0.943), disk area (p = 0.515), rim area (p = 0.294), rim volume (p = 0.118), C/D area R (p = 0.103), RNFL Average (p = 0.632), RNFL Superior (p = 0.283) and RNFL Inferior (p = 0.488) were not statistically significantly different between the groups. Conclusion. OCT measurements of the RNFL thickness provide clinically significant information in monitoring of glaucomatous changes. There are no differences in the patterns of RNFL defects per sectors and quadrants between NTG and HTG, measured by OCT.http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600068T.pdfglaucoma, open-angleintraocular pressuretomography, optical coherence |
| spellingShingle | Trenkić-Božinović Marija Zlatanović Gordana Jovanović Predrag Veselinović Dragan Đorđević-Jocić Jasmina Radenković Marija Resan Mirko Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure Vojnosanitetski Pregled glaucoma, open-angle intraocular pressure tomography, optical coherence |
| title | Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure |
| title_full | Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure |
| title_fullStr | Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure |
| title_full_unstemmed | Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure |
| title_short | Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure |
| title_sort | optical coherence tomography in the evaluation of structural changes in primary open angle glaucoma with and without elevated intraocular pressure |
| topic | glaucoma, open-angle intraocular pressure tomography, optical coherence |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600068T.pdf |
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