Pre-clinical study of curcumin in the treatment of gastric Cancer
Gastric cancer is the fifth most common cancer globally and the third leading cause of cancer-related deaths. Researchers have been investigating natural compounds as potential alternatives to traditional cancer treatments, including surgery, radiation, and chemotherapy. One such compound is curcumi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000192 |
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| _version_ | 1823864406201597952 |
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| author | Minghui Hao Chungang Zhang |
| author_facet | Minghui Hao Chungang Zhang |
| author_sort | Minghui Hao |
| collection | DOAJ |
| description | Gastric cancer is the fifth most common cancer globally and the third leading cause of cancer-related deaths. Researchers have been investigating natural compounds as potential alternatives to traditional cancer treatments, including surgery, radiation, and chemotherapy. One such compound is curcumin, which is derived from the rhizome of the turmeric plant. It possesses both edible and medicinal properties and has exhibited various biological activities that are beneficial for the treatment of gastric cancer. However, its clinical use is hindered by challenges such as poor water solubility, low bioavailability, and rapid metabolism. This review aims to summarize the mechanisms through which curcumin affects gastric cancer in both laboratory and animal studies, while also discussing effective strategies for enhancing its therapeutic application. |
| format | Article |
| id | doaj-art-70430f3b5ab647ccb6919d7661a3b389 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-70430f3b5ab647ccb6919d7661a3b3892025-02-09T04:59:56ZengElsevierJournal of Functional Foods1756-46462025-02-01125106677Pre-clinical study of curcumin in the treatment of gastric CancerMinghui Hao0Chungang Zhang1College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China; Department of Pharmacy, Changzhi Medical College, Changzhi, China; Qimeng Co., LTD, Chifeng, China; Corresponding author at: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, No. 77, Life One Road, DD port, Dalian 116600, China.Gastric cancer is the fifth most common cancer globally and the third leading cause of cancer-related deaths. Researchers have been investigating natural compounds as potential alternatives to traditional cancer treatments, including surgery, radiation, and chemotherapy. One such compound is curcumin, which is derived from the rhizome of the turmeric plant. It possesses both edible and medicinal properties and has exhibited various biological activities that are beneficial for the treatment of gastric cancer. However, its clinical use is hindered by challenges such as poor water solubility, low bioavailability, and rapid metabolism. This review aims to summarize the mechanisms through which curcumin affects gastric cancer in both laboratory and animal studies, while also discussing effective strategies for enhancing its therapeutic application.http://www.sciencedirect.com/science/article/pii/S1756464625000192CurcuminGastric cancerMechanismEfficient treatment |
| spellingShingle | Minghui Hao Chungang Zhang Pre-clinical study of curcumin in the treatment of gastric Cancer Journal of Functional Foods Curcumin Gastric cancer Mechanism Efficient treatment |
| title | Pre-clinical study of curcumin in the treatment of gastric Cancer |
| title_full | Pre-clinical study of curcumin in the treatment of gastric Cancer |
| title_fullStr | Pre-clinical study of curcumin in the treatment of gastric Cancer |
| title_full_unstemmed | Pre-clinical study of curcumin in the treatment of gastric Cancer |
| title_short | Pre-clinical study of curcumin in the treatment of gastric Cancer |
| title_sort | pre clinical study of curcumin in the treatment of gastric cancer |
| topic | Curcumin Gastric cancer Mechanism Efficient treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000192 |
| work_keys_str_mv | AT minghuihao preclinicalstudyofcurcumininthetreatmentofgastriccancer AT chungangzhang preclinicalstudyofcurcumininthetreatmentofgastriccancer |