Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis.
<h4>Background</h4>Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Librar...
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278102&type=printable |
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| author | Tzu-Rong Peng Fang-Pei Tsai Ta-Wei Wu |
| author_facet | Tzu-Rong Peng Fang-Pei Tsai Ta-Wei Wu |
| author_sort | Tzu-Rong Peng |
| collection | DOAJ |
| description | <h4>Background</h4>Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Library for the randomized control trials (RCTs) of interventions for preventing and treating OM. Network meta-analysis (NMA) was performed to estimate odds ratios (ORs) and 95% confidence intervals (CI) from both direct and indirect evidence. The prespecified primary efficacy outcome was the treatment effect of moderate to severe oral mucositis with 12 interventions. The outcome was moderate to a severe grade of OM.<h4>Results</h4>This study included 55 RCTs with 3,552 participants. The results showed that honey significantly lowered the risk of chemo/radiotherapy-induced moderate to severe oral mucositis than placebo (OR: 0.01, 95%CI 0.00 to 0.45), followed by lignocaine (OR: 0.07, 95%CI 0.00 to 0.95). The surface under cumulative ranking curve (SUCRA) values for honey were 0.95, followed by lignocaine (SUCRA, 0.81) and benzydamine (SUCRA, 0.78).<h4>Conclusions</h4>The honey is effective for patients with cancer undergoing chemotherapy or radiotherapy-induced oral mucositis. |
| format | Article |
| id | doaj-art-70420160cdf74c5b8c198b1df19e7de7 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-70420160cdf74c5b8c198b1df19e7de72025-08-20T02:28:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712e027810210.1371/journal.pone.0278102Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis.Tzu-Rong PengFang-Pei TsaiTa-Wei Wu<h4>Background</h4>Oral mucositis (OM) is a common side effect of chemotherapy and radiotherapy in patients with cancers. The prevention or treatment of OM in cancer patients is crucial in the treatment of cancer.<h4>Methods</h4>We searched PubMed, Embase, and Cochrane Library for the randomized control trials (RCTs) of interventions for preventing and treating OM. Network meta-analysis (NMA) was performed to estimate odds ratios (ORs) and 95% confidence intervals (CI) from both direct and indirect evidence. The prespecified primary efficacy outcome was the treatment effect of moderate to severe oral mucositis with 12 interventions. The outcome was moderate to a severe grade of OM.<h4>Results</h4>This study included 55 RCTs with 3,552 participants. The results showed that honey significantly lowered the risk of chemo/radiotherapy-induced moderate to severe oral mucositis than placebo (OR: 0.01, 95%CI 0.00 to 0.45), followed by lignocaine (OR: 0.07, 95%CI 0.00 to 0.95). The surface under cumulative ranking curve (SUCRA) values for honey were 0.95, followed by lignocaine (SUCRA, 0.81) and benzydamine (SUCRA, 0.78).<h4>Conclusions</h4>The honey is effective for patients with cancer undergoing chemotherapy or radiotherapy-induced oral mucositis.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278102&type=printable |
| spellingShingle | Tzu-Rong Peng Fang-Pei Tsai Ta-Wei Wu Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. PLoS ONE |
| title | Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. |
| title_full | Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. |
| title_fullStr | Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. |
| title_full_unstemmed | Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. |
| title_short | Effects of various treatments for preventing oral mucositis in cancer patients: A network meta-analysis. |
| title_sort | effects of various treatments for preventing oral mucositis in cancer patients a network meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278102&type=printable |
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