Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat
There is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental findings indicate that a combination of lipophilic statins with phosphodiesterase type-5 inhibitor, sildenafil, can offer preventive effects...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2014-09-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2014-0029 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832572414733582336 |
|---|---|
| author | Jasińska-Stroschein Magdalena Owczarek Jacek Wesołowska Anna Orszulak-Michalak Daria |
| author_facet | Jasińska-Stroschein Magdalena Owczarek Jacek Wesołowska Anna Orszulak-Michalak Daria |
| author_sort | Jasińska-Stroschein Magdalena |
| collection | DOAJ |
| description | There is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental findings indicate that a combination of lipophilic statins with phosphodiesterase type-5 inhibitor, sildenafil, can offer preventive effects on rat monocrotaline-induced pulmonary hypertension. The present study is aimed to assess whether therapeutic regimen provides any benefits. Seven days after pulmonary hypertension induction, hydrophilic rosuvastatin and sildenafil were given for 14 days to male Wistar outbred rats. Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. The present study demonstrates that administration of hydrophilic statin with sildenafil results in reduction of pulmonary vascular remodeling and right ventricular pressure. The results of biochemical measurements may suggest that statins play a positive role in right ventricle function or the process of angiogenesis in pulmonary hypertension development. |
| format | Article |
| id | doaj-art-704166e0a9ba498999fd6e406e65763a |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-704166e0a9ba498999fd6e406e65763a2025-02-02T10:03:16ZengSciendoActa Pharmaceutica1846-95582014-09-0164334535310.2478/acph-2014-0029acph-2014-0029Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in RatJasińska-Stroschein Magdalena0Owczarek Jacek1Wesołowska Anna2Orszulak-Michalak Daria3Department of Biopharmacy Medical University of Łódź Łódź, PolandDepartment of Biopharmacy Medical University of Łódź Łódź, PolandDepartment of Biopharmacy Medical University of Łódź Łódź, PolandDepartment of Biopharmacy Medical University of Łódź Łódź, PolandThere is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental findings indicate that a combination of lipophilic statins with phosphodiesterase type-5 inhibitor, sildenafil, can offer preventive effects on rat monocrotaline-induced pulmonary hypertension. The present study is aimed to assess whether therapeutic regimen provides any benefits. Seven days after pulmonary hypertension induction, hydrophilic rosuvastatin and sildenafil were given for 14 days to male Wistar outbred rats. Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. The present study demonstrates that administration of hydrophilic statin with sildenafil results in reduction of pulmonary vascular remodeling and right ventricular pressure. The results of biochemical measurements may suggest that statins play a positive role in right ventricle function or the process of angiogenesis in pulmonary hypertension development.https://doi.org/10.2478/acph-2014-0029rosuvastatinsildenafilcombination therapypulmonary hypertensionhemodynamic parameters |
| spellingShingle | Jasińska-Stroschein Magdalena Owczarek Jacek Wesołowska Anna Orszulak-Michalak Daria Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat Acta Pharmaceutica rosuvastatin sildenafil combination therapy pulmonary hypertension hemodynamic parameters |
| title | Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat |
| title_full | Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat |
| title_fullStr | Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat |
| title_full_unstemmed | Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat |
| title_short | Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat |
| title_sort | rosuvastatin sildenafil and their combination in monocrotaline induced pulmonary hypertension in rat |
| topic | rosuvastatin sildenafil combination therapy pulmonary hypertension hemodynamic parameters |
| url | https://doi.org/10.2478/acph-2014-0029 |
| work_keys_str_mv | AT jasinskastroscheinmagdalena rosuvastatinsildenafilandtheircombinationinmonocrotalineinducedpulmonaryhypertensioninrat AT owczarekjacek rosuvastatinsildenafilandtheircombinationinmonocrotalineinducedpulmonaryhypertensioninrat AT wesołowskaanna rosuvastatinsildenafilandtheircombinationinmonocrotalineinducedpulmonaryhypertensioninrat AT orszulakmichalakdaria rosuvastatinsildenafilandtheircombinationinmonocrotalineinducedpulmonaryhypertensioninrat |