Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases
The troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle. Troponin I, a subunit of this complex, inhibits actomyosin interactions during...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Animal Cells and Systems |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19768354.2025.2533821 |
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| author | Dongju Han Younghyun Lim Soah Lee Seong-il Eyun |
| author_facet | Dongju Han Younghyun Lim Soah Lee Seong-il Eyun |
| author_sort | Dongju Han |
| collection | DOAJ |
| description | The troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle. Troponin I, a subunit of this complex, inhibits actomyosin interactions during muscle relaxation. Its function is finely tuned by posttranslational modifications, particularly phosphorylation, which influence calcium sensitivity and actin affinity, thus impacting muscle contraction. Mutations in troponin I are closely associated with various human diseases. Specifically, several mutations in cardiac troponin I have been linked to cardiomyopathies, such as hypertrophic, dilated, and restrictive cardiomyopathies, which affect heart contractility and calcium handling. In this review, we explore the multifaceted aspects of troponin I, including its structure, functional role in muscle contraction, evolution, and the complex interactions between posttranslational modifications and genetic mutations that alter its function and contribute to disease progression. |
| format | Article |
| id | doaj-art-703c43ac17f4477b8cb5973f3a7fa3c4 |
| institution | Kabale University |
| issn | 1976-8354 2151-2485 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj-art-703c43ac17f4477b8cb5973f3a7fa3c42025-08-20T03:56:50ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852025-12-0129144646810.1080/19768354.2025.2533821Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseasesDongju Han0Younghyun Lim1Soah Lee2Seong-il Eyun3Department of Life Science, Chung-Ang University, Seoul, KoreaDepartment of Life Science, Chung-Ang University, Seoul, KoreaDepartment of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, KoreaDepartment of Life Science, Chung-Ang University, Seoul, KoreaThe troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle. Troponin I, a subunit of this complex, inhibits actomyosin interactions during muscle relaxation. Its function is finely tuned by posttranslational modifications, particularly phosphorylation, which influence calcium sensitivity and actin affinity, thus impacting muscle contraction. Mutations in troponin I are closely associated with various human diseases. Specifically, several mutations in cardiac troponin I have been linked to cardiomyopathies, such as hypertrophic, dilated, and restrictive cardiomyopathies, which affect heart contractility and calcium handling. In this review, we explore the multifaceted aspects of troponin I, including its structure, functional role in muscle contraction, evolution, and the complex interactions between posttranslational modifications and genetic mutations that alter its function and contribute to disease progression.https://www.tandfonline.com/doi/10.1080/19768354.2025.2533821Troponin Icardiomyopathyevolution of troponin Ipost-transcriptional modification of troponin Igenetic mutations in troponin I |
| spellingShingle | Dongju Han Younghyun Lim Soah Lee Seong-il Eyun Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases Animal Cells and Systems Troponin I cardiomyopathy evolution of troponin I post-transcriptional modification of troponin I genetic mutations in troponin I |
| title | Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases |
| title_full | Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases |
| title_fullStr | Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases |
| title_full_unstemmed | Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases |
| title_short | Troponin I – a comprehensive review of its function, structure, evolution, and role in muscle diseases |
| title_sort | troponin i a comprehensive review of its function structure evolution and role in muscle diseases |
| topic | Troponin I cardiomyopathy evolution of troponin I post-transcriptional modification of troponin I genetic mutations in troponin I |
| url | https://www.tandfonline.com/doi/10.1080/19768354.2025.2533821 |
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