Beneath the surface: unveiling the gut–brain axis in anorexia and depression
Abstract Anorexia nervosa (AN) and depression are complex conditions with high comorbidity, impacting mental and physical health. Recent research suggests gut microbiota plays a significant role in their development and progression. This correspondence highlights the critical gaps in understanding t...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Eating and Weight Disorders |
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| Online Access: | https://doi.org/10.1007/s40519-025-01719-2 |
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| author | Fatima Shahid Zain Afridi Muhammad Ali Muhammad Nabeel Saddique Javed Iqbal Anurag Jha |
| author_facet | Fatima Shahid Zain Afridi Muhammad Ali Muhammad Nabeel Saddique Javed Iqbal Anurag Jha |
| author_sort | Fatima Shahid |
| collection | DOAJ |
| description | Abstract Anorexia nervosa (AN) and depression are complex conditions with high comorbidity, impacting mental and physical health. Recent research suggests gut microbiota plays a significant role in their development and progression. This correspondence highlights the critical gaps in understanding the gut–brain axis in AN and depression, emphasizing the need for comprehensive research. We discuss recent findings, including altered gut microbiota profiles and inflammatory factors, and identify key areas for future investigation. These include large-scale, multi-center studies to quantify microbiota profiles, mechanistic understanding of gut microbiota alterations, and diagnostic and therapeutic advances using microbiota as biomarkers. Addressing these gaps is crucial for developing effective treatment strategies and improving patient outcomes. By exploring the underlying mechanisms, validating biomarkers, and developing targeted therapies, we can enhance diagnostic accuracy, improve treatment outcomes, and better support patients with AN and depression. This research has the potential to transform the management of these conditions and improve quality of life for those affected. Level of evidence Low level of evidence as it is a personal opinion. |
| format | Article |
| id | doaj-art-703896418da042c3b3e618c29e611f04 |
| institution | Kabale University |
| issn | 1590-1262 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Eating and Weight Disorders |
| spelling | doaj-art-703896418da042c3b3e618c29e611f042025-02-09T12:04:43ZengSpringerEating and Weight Disorders1590-12622025-02-013011310.1007/s40519-025-01719-2Beneath the surface: unveiling the gut–brain axis in anorexia and depressionFatima Shahid0Zain Afridi1Muhammad Ali2Muhammad Nabeel Saddique3Javed Iqbal4Anurag Jha5King Edward Medical UniversityKhyber Medical UniversityKhyber Medical UniversityKing Edward Medical UniversityHamad Medical CorporationKing Edward Medical UniversityAbstract Anorexia nervosa (AN) and depression are complex conditions with high comorbidity, impacting mental and physical health. Recent research suggests gut microbiota plays a significant role in their development and progression. This correspondence highlights the critical gaps in understanding the gut–brain axis in AN and depression, emphasizing the need for comprehensive research. We discuss recent findings, including altered gut microbiota profiles and inflammatory factors, and identify key areas for future investigation. These include large-scale, multi-center studies to quantify microbiota profiles, mechanistic understanding of gut microbiota alterations, and diagnostic and therapeutic advances using microbiota as biomarkers. Addressing these gaps is crucial for developing effective treatment strategies and improving patient outcomes. By exploring the underlying mechanisms, validating biomarkers, and developing targeted therapies, we can enhance diagnostic accuracy, improve treatment outcomes, and better support patients with AN and depression. This research has the potential to transform the management of these conditions and improve quality of life for those affected. Level of evidence Low level of evidence as it is a personal opinion.https://doi.org/10.1007/s40519-025-01719-2Gut microbiotaAnorexia nervosaMajor depressive disorderBiomarkers |
| spellingShingle | Fatima Shahid Zain Afridi Muhammad Ali Muhammad Nabeel Saddique Javed Iqbal Anurag Jha Beneath the surface: unveiling the gut–brain axis in anorexia and depression Eating and Weight Disorders Gut microbiota Anorexia nervosa Major depressive disorder Biomarkers |
| title | Beneath the surface: unveiling the gut–brain axis in anorexia and depression |
| title_full | Beneath the surface: unveiling the gut–brain axis in anorexia and depression |
| title_fullStr | Beneath the surface: unveiling the gut–brain axis in anorexia and depression |
| title_full_unstemmed | Beneath the surface: unveiling the gut–brain axis in anorexia and depression |
| title_short | Beneath the surface: unveiling the gut–brain axis in anorexia and depression |
| title_sort | beneath the surface unveiling the gut brain axis in anorexia and depression |
| topic | Gut microbiota Anorexia nervosa Major depressive disorder Biomarkers |
| url | https://doi.org/10.1007/s40519-025-01719-2 |
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