Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021
Abstract Background Female-specific cancers, particularly breast, cervical, ovarian, and uterine cancers, account for nearly 40% of all cancers in women. This study aimed to analyze the global epidemiological trends of these cancers from 1990 to 2021, offering insights into their evolving patterns a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-025-01660-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544363890442240 |
|---|---|
| author | Tianye Li Haoxiang Zhang Mengyi Lian Qionghua He Mingwei Lv Lingyun Zhai Jianwei Zhou Kongming Wu Ming Yi |
| author_facet | Tianye Li Haoxiang Zhang Mengyi Lian Qionghua He Mingwei Lv Lingyun Zhai Jianwei Zhou Kongming Wu Ming Yi |
| author_sort | Tianye Li |
| collection | DOAJ |
| description | Abstract Background Female-specific cancers, particularly breast, cervical, ovarian, and uterine cancers, account for nearly 40% of all cancers in women. This study aimed to analyze the global epidemiological trends of these cancers from 1990 to 2021, offering insights into their evolving patterns and providing valuable information for health policymakers to allocate healthcare resources more effectively. Methods Data from the Global Burden of Disease Study 2021 (GBD 2021) were used to comprehensively assess the global incidence, mortality, and disability-adjusted life years (DALYs) of female-specific cancers. Age-standardized rates facilitated cross-regional comparisons, accounting for differences in population size and demographics. The socio-demographic index (SDI) was employed to categorize regions and evaluate correlations between cancer burden and economic level. In addition, risk factors attributable to female-specific cancer deaths and DALYs were assessed based on the comparative risk assessment model of the GBD project. Results From 1990 to 2021, the global burden of female-specific cancers increased at varying rates. In 2021, breast cancer accounted for 2.08 million incident cases, 0.66 million deaths, and 20.25 million DALYs globally. In comparison, cervical, ovarian, and uterine cancers had lower burdens, with 0.67 million, 0.30 million, and 0.47 million incident cases, respectively. Age-standardized rates of breast, ovarian, and uterine cancers showed positive correlations with SDI, while cervical cancer exhibited a negative correlation. Attributable risk factors for breast cancer-associated deaths in 2021 included dietary risks, high body-mass index (BMI), high fasting plasma glucose, alcohol use, tobacco use, and low physical activity. Additional risk factors were unsafe sex and tobacco use for cervical cancer, high BMI and occupational risks for ovarian cancer, and high BMI for uterine cancer. Conclusions The burden of female-specific cancers has increased in recent decades, with significant demographic and regional discrepancies. These findings highlight the urgent need for targeted public health interventions to mitigate the global impact of these cancers. |
| format | Article |
| id | doaj-art-7035c25943c14c1abf7a94c39fdbb9bd |
| institution | Kabale University |
| issn | 1756-8722 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj-art-7035c25943c14c1abf7a94c39fdbb9bd2025-01-12T12:36:35ZengBMCJournal of Hematology & Oncology1756-87222025-01-0118112510.1186/s13045-025-01660-yGlobal status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021Tianye Li0Haoxiang Zhang1Mengyi Lian2Qionghua He3Mingwei Lv4Lingyun Zhai5Jianwei Zhou6Kongming Wu7Ming Yi8Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang UniversityDepartment of Hepatopancreatobiliary Surgery, Fujian Provincial HospitalDepartment of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang UniversityDepartment of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang UniversityDepartment of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang UniversityDepartment of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang UniversityCancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical UniversityDepartment of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityAbstract Background Female-specific cancers, particularly breast, cervical, ovarian, and uterine cancers, account for nearly 40% of all cancers in women. This study aimed to analyze the global epidemiological trends of these cancers from 1990 to 2021, offering insights into their evolving patterns and providing valuable information for health policymakers to allocate healthcare resources more effectively. Methods Data from the Global Burden of Disease Study 2021 (GBD 2021) were used to comprehensively assess the global incidence, mortality, and disability-adjusted life years (DALYs) of female-specific cancers. Age-standardized rates facilitated cross-regional comparisons, accounting for differences in population size and demographics. The socio-demographic index (SDI) was employed to categorize regions and evaluate correlations between cancer burden and economic level. In addition, risk factors attributable to female-specific cancer deaths and DALYs were assessed based on the comparative risk assessment model of the GBD project. Results From 1990 to 2021, the global burden of female-specific cancers increased at varying rates. In 2021, breast cancer accounted for 2.08 million incident cases, 0.66 million deaths, and 20.25 million DALYs globally. In comparison, cervical, ovarian, and uterine cancers had lower burdens, with 0.67 million, 0.30 million, and 0.47 million incident cases, respectively. Age-standardized rates of breast, ovarian, and uterine cancers showed positive correlations with SDI, while cervical cancer exhibited a negative correlation. Attributable risk factors for breast cancer-associated deaths in 2021 included dietary risks, high body-mass index (BMI), high fasting plasma glucose, alcohol use, tobacco use, and low physical activity. Additional risk factors were unsafe sex and tobacco use for cervical cancer, high BMI and occupational risks for ovarian cancer, and high BMI for uterine cancer. Conclusions The burden of female-specific cancers has increased in recent decades, with significant demographic and regional discrepancies. These findings highlight the urgent need for targeted public health interventions to mitigate the global impact of these cancers.https://doi.org/10.1186/s13045-025-01660-yFemale-specific cancerBreast cancerCervical cancer, Ovarian cancer, Uterine cancerSocio-demographic indexCancer epidemiology |
| spellingShingle | Tianye Li Haoxiang Zhang Mengyi Lian Qionghua He Mingwei Lv Lingyun Zhai Jianwei Zhou Kongming Wu Ming Yi Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 Journal of Hematology & Oncology Female-specific cancer Breast cancer Cervical cancer, Ovarian cancer, Uterine cancer Socio-demographic index Cancer epidemiology |
| title | Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 |
| title_full | Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 |
| title_fullStr | Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 |
| title_full_unstemmed | Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 |
| title_short | Global status and attributable risk factors of breast, cervical, ovarian, and uterine cancers from 1990 to 2021 |
| title_sort | global status and attributable risk factors of breast cervical ovarian and uterine cancers from 1990 to 2021 |
| topic | Female-specific cancer Breast cancer Cervical cancer, Ovarian cancer, Uterine cancer Socio-demographic index Cancer epidemiology |
| url | https://doi.org/10.1186/s13045-025-01660-y |
| work_keys_str_mv | AT tianyeli globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT haoxiangzhang globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT mengyilian globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT qionghuahe globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT mingweilv globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT lingyunzhai globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT jianweizhou globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT kongmingwu globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 AT mingyi globalstatusandattributableriskfactorsofbreastcervicalovariananduterinecancersfrom1990to2021 |