Research progress on the role of FGF21 in insulin resistance
The elevated global prevalence of metabolic syndrome and type 2 diabetes mellitus (T2DM) has led to a dramatic increase in patients with insulin resistance. The majority of insulin resistance is closely associated with obesity and metabolic syndrome, resulting in impaired insulin signaling pathways....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1619462/full |
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| author | Haixin Zhang Rongyu Zhu Quanhao Sun Likun Du |
| author_facet | Haixin Zhang Rongyu Zhu Quanhao Sun Likun Du |
| author_sort | Haixin Zhang |
| collection | DOAJ |
| description | The elevated global prevalence of metabolic syndrome and type 2 diabetes mellitus (T2DM) has led to a dramatic increase in patients with insulin resistance. The majority of insulin resistance is closely associated with obesity and metabolic syndrome, resulting in impaired insulin signaling pathways. type 2 diabetes can be preceded by insulin resistance, and therefore, it is crucial to stop the progression of insulin resistance to type 2 diabetes. Fibroblast growth factor 21 (FGF21) holds a bright future in the therapeutic study of insulin resistance; it is involved in the regulation of lipid metabolism and immune homeostasis while ameliorating the impaired insulin signaling pathway, improving the state of insulin resistance through multiple aspects. In this review, we describe the physiological properties and signaling pathways of FGF21 and elaborate on the mechanism of action of FGF21 in improving insulin resistance. Finally, the progress of FGF21 analog research is summarized in the context of the treatment of insulin resistance. |
| format | Article |
| id | doaj-art-70352dbcf0574d528118b130e86e6ee7 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-70352dbcf0574d528118b130e86e6ee72025-08-20T03:36:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.16194621619462Research progress on the role of FGF21 in insulin resistanceHaixin Zhang0Rongyu Zhu1Quanhao Sun2Likun Du3School of Graduate Students, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSchool of Graduate Students, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaSchool of Graduate Students, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaThe Second Department of Endocrine Diseases, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaThe elevated global prevalence of metabolic syndrome and type 2 diabetes mellitus (T2DM) has led to a dramatic increase in patients with insulin resistance. The majority of insulin resistance is closely associated with obesity and metabolic syndrome, resulting in impaired insulin signaling pathways. type 2 diabetes can be preceded by insulin resistance, and therefore, it is crucial to stop the progression of insulin resistance to type 2 diabetes. Fibroblast growth factor 21 (FGF21) holds a bright future in the therapeutic study of insulin resistance; it is involved in the regulation of lipid metabolism and immune homeostasis while ameliorating the impaired insulin signaling pathway, improving the state of insulin resistance through multiple aspects. In this review, we describe the physiological properties and signaling pathways of FGF21 and elaborate on the mechanism of action of FGF21 in improving insulin resistance. Finally, the progress of FGF21 analog research is summarized in the context of the treatment of insulin resistance.https://www.frontiersin.org/articles/10.3389/fendo.2025.1619462/fullinsulin resistanceFGF21signaling pathwayglucosehyperinsulinemia |
| spellingShingle | Haixin Zhang Rongyu Zhu Quanhao Sun Likun Du Research progress on the role of FGF21 in insulin resistance Frontiers in Endocrinology insulin resistance FGF21 signaling pathway glucose hyperinsulinemia |
| title | Research progress on the role of FGF21 in insulin resistance |
| title_full | Research progress on the role of FGF21 in insulin resistance |
| title_fullStr | Research progress on the role of FGF21 in insulin resistance |
| title_full_unstemmed | Research progress on the role of FGF21 in insulin resistance |
| title_short | Research progress on the role of FGF21 in insulin resistance |
| title_sort | research progress on the role of fgf21 in insulin resistance |
| topic | insulin resistance FGF21 signaling pathway glucose hyperinsulinemia |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1619462/full |
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