A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane
The dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at the blood–membrane interface, aiming to achieve antithrombogenic and antifouling effects. This study aimed to assess the performance and albumin loss of the Hydrolink NV dial...
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MDPI AG
2025-01-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/15/1/30 |
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| author | Francisco Maduell Victor Joaquín Escudero-Saiz Elena Cuadrado-Payán Maria Rodriguez-Garcia Miquel Gómez Lida María Rodas Néstor Fontseré Maria del Carmen Salgado Gregori Casals Nayra Rico José Jesús Broseta |
| author_facet | Francisco Maduell Victor Joaquín Escudero-Saiz Elena Cuadrado-Payán Maria Rodriguez-Garcia Miquel Gómez Lida María Rodas Néstor Fontseré Maria del Carmen Salgado Gregori Casals Nayra Rico José Jesús Broseta |
| author_sort | Francisco Maduell |
| collection | DOAJ |
| description | The dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at the blood–membrane interface, aiming to achieve antithrombogenic and antifouling effects. This study aimed to assess the performance and albumin loss of the Hydrolink NV dialyzer in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) with different infusion flows (Qis) and compare it with the hydrophilic FX CorAL dialyzer in post-dilution HDF. A prospective study was carried out in 20 patients. Patients underwent five dialysis sessions with the same routine dialysis parameters: four sessions with the Toraylight NV 2.1 (HD, post-dilution HDF with 50, 75 or auto-substitution Qi) and one with the FX CorAL 800 (post-dilution HDF with auto-substitution Qi). The reduction ratios’ (RRs’) wide range of molecular weight molecules were assessed and the dialysate albumin loss was quantified. The lowest β<sub>2</sub>-microglobulin, indoxyl-sulfate, and p-cresyl sulfate RR values were observed with the Toraylight NV 2.1 in HD, and they improved progressively with an increased Qi, without differences being observed between the two dialyzers in auto-substitution. A different removal profile was observed in terms of myoglobin, kFLC, prolactin, α<sub>1</sub>-microglobulin, α<sub>1</sub>-acid glycoprotein, and λFLC, whose RRs also improved progressively with an increased Qi but were significantly higher with the Toraylight NV than the CorAL in the same convective condition. There were significant differences in the albumin dialysate losses, with the highest value obtained with the Toraylight NV in auto-substitution HDF, with more than 50% of patients surpassing 5 g per session. The Toraylight NV dialyzer has great potential for efficacy but should be used at the optimal convective volume (Qi not exceeding 75 mL/min or FF not exceeding 25%) to avoid excessive albumin loss. |
| format | Article |
| id | doaj-art-70349273959c4eeb84dc1da8296549a3 |
| institution | Kabale University |
| issn | 2077-0375 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj-art-70349273959c4eeb84dc1da8296549a32025-01-24T13:41:05ZengMDPI AGMembranes2077-03752025-01-011513010.3390/membranes15010030A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis MembraneFrancisco Maduell0Victor Joaquín Escudero-Saiz1Elena Cuadrado-Payán2Maria Rodriguez-Garcia3Miquel Gómez4Lida María Rodas5Néstor Fontseré6Maria del Carmen Salgado7Gregori Casals8Nayra Rico9José Jesús Broseta10Nephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic de Barcelona, 08036 Barcelona, SpainBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic de Barcelona, 08036 Barcelona, SpainBiochemistry and Molecular Genetics Department-CDB, Hospital Clínic de Barcelona, 08036 Barcelona, SpainNephrology and Renal Transplantation, Hospital Clínic de Barcelona, 08036 Barcelona, SpainThe dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at the blood–membrane interface, aiming to achieve antithrombogenic and antifouling effects. This study aimed to assess the performance and albumin loss of the Hydrolink NV dialyzer in hemodialysis (HD) and post-dilution hemodiafiltration (HDF) with different infusion flows (Qis) and compare it with the hydrophilic FX CorAL dialyzer in post-dilution HDF. A prospective study was carried out in 20 patients. Patients underwent five dialysis sessions with the same routine dialysis parameters: four sessions with the Toraylight NV 2.1 (HD, post-dilution HDF with 50, 75 or auto-substitution Qi) and one with the FX CorAL 800 (post-dilution HDF with auto-substitution Qi). The reduction ratios’ (RRs’) wide range of molecular weight molecules were assessed and the dialysate albumin loss was quantified. The lowest β<sub>2</sub>-microglobulin, indoxyl-sulfate, and p-cresyl sulfate RR values were observed with the Toraylight NV 2.1 in HD, and they improved progressively with an increased Qi, without differences being observed between the two dialyzers in auto-substitution. A different removal profile was observed in terms of myoglobin, kFLC, prolactin, α<sub>1</sub>-microglobulin, α<sub>1</sub>-acid glycoprotein, and λFLC, whose RRs also improved progressively with an increased Qi but were significantly higher with the Toraylight NV than the CorAL in the same convective condition. There were significant differences in the albumin dialysate losses, with the highest value obtained with the Toraylight NV in auto-substitution HDF, with more than 50% of patients surpassing 5 g per session. The Toraylight NV dialyzer has great potential for efficacy but should be used at the optimal convective volume (Qi not exceeding 75 mL/min or FF not exceeding 25%) to avoid excessive albumin loss.https://www.mdpi.com/2077-0375/15/1/30dialysate albumin lossdialyzer performancehemodiafiltrationhydrophilic membrane |
| spellingShingle | Francisco Maduell Victor Joaquín Escudero-Saiz Elena Cuadrado-Payán Maria Rodriguez-Garcia Miquel Gómez Lida María Rodas Néstor Fontseré Maria del Carmen Salgado Gregori Casals Nayra Rico José Jesús Broseta A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane Membranes dialysate albumin loss dialyzer performance hemodiafiltration hydrophilic membrane |
| title | A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane |
| title_full | A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane |
| title_fullStr | A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane |
| title_full_unstemmed | A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane |
| title_short | A Study on the Safety and Efficacy of an Innovative Hydrophilic Dialysis Membrane |
| title_sort | study on the safety and efficacy of an innovative hydrophilic dialysis membrane |
| topic | dialysate albumin loss dialyzer performance hemodiafiltration hydrophilic membrane |
| url | https://www.mdpi.com/2077-0375/15/1/30 |
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