Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score
Introduction: The Dental Apical Inflammation Score (DAIS) is a semi-quantitative histopathological score used to categorise apical inflammatory lesions. This score has shown clinical potential for assessment of wound-healing and infection risk in post-apical lesions. Objective: This retrospective st...
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Elsevier
2025-03-01
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| Series: | Advances in Oral and Maxillofacial Surgery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667147624000323 |
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| author | Pascal Grün Sepideh Hatamikia Ruva Jadadic Arb Gjergjindreaj Lars Jansen Florian Pfaffeneder-Mantai Sebastian Fitzek Margit Mostegel Kyung-Eun Anna Choi Dritan Turhani |
| author_facet | Pascal Grün Sepideh Hatamikia Ruva Jadadic Arb Gjergjindreaj Lars Jansen Florian Pfaffeneder-Mantai Sebastian Fitzek Margit Mostegel Kyung-Eun Anna Choi Dritan Turhani |
| author_sort | Pascal Grün |
| collection | DOAJ |
| description | Introduction: The Dental Apical Inflammation Score (DAIS) is a semi-quantitative histopathological score used to categorise apical inflammatory lesions. This score has shown clinical potential for assessment of wound-healing and infection risk in post-apical lesions. Objective: This retrospective study aimed to investigate whether periapical lesion volume measurements obtained using manual segmentation on cone-beam computed tomography (CBCT) scans were related to the DAIS categorisation. In addition, the correlations of periapical lesion volume with treatment, anatomical sites, and histological diagnosis criteria were explored. Material and methods: CBCT scans and histopathological findings of specimens from a cohort of 153 patients were used in this study. Volumetric measurement of the apical lesions was performed using MeVisLab© software. Fisher's exact test and Kruskal–Wallis H-test were performed to examine the relationship between lesion volume and different factors. Results: Lesions with a DAIS of 4 showed a significantly larger mean volume than those with a DAIS of 2 (p-value of 0.0377). Lesion volumes also showed a significant difference (p-value of 0.0157) in relation to the histological diagnosis types, with diagnosis based on the presence of radicular cysts being associated with a larger mean lesion volume than that based on the proportion of radicular cysts. Discussion/conclusions: The volume of the preoperative periapical lesion correlates with both the DAIS category and histological diagnosis and can be used to assess inflammatory infiltrations, facilitating clinical decision-making and treatment-plan optimisation. |
| format | Article |
| id | doaj-art-703000fa694448c9b32cf13b6639de8e |
| institution | Kabale University |
| issn | 2667-1476 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Oral and Maxillofacial Surgery |
| spelling | doaj-art-703000fa694448c9b32cf13b6639de8e2024-12-29T04:48:14ZengElsevierAdvances in Oral and Maxillofacial Surgery2667-14762025-03-0117100510Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation scorePascal Grün0Sepideh Hatamikia1Ruva Jadadic2Arb Gjergjindreaj3Lars Jansen4Florian Pfaffeneder-Mantai5Sebastian Fitzek6Margit Mostegel7Kyung-Eun Anna Choi8Dritan Turhani9Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaResearch Center for Clinical AI-Research in Omics and Medical Data Science (CAROM), Department of Medicine, Danube Private University, Steiner Landstraße 124, 3500, Krems, Austria; Austrian Center for Medical Innovation and Technology, Viktor Kaplan-Straße 2/1, 2700, Wiener Neustadt, AustriaCenter for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaCenter for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaCenter for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaCenter for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, Austria; Division for Chemistry and Physics of Materials, Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaHealth Services Research Group, Medical Images Analysis and Artificial Intelligence (MIAAI), Danube Private University, Steiner Landstraße 124, 3500, Krems, AustriaADK Diagnostics GmbH, Panikengasse 45, 1160, Vienna, AustriaHealth Services Research Group, Medical Images Analysis and Artificial Intelligence (MIAAI), Danube Private University, Steiner Landstraße 124, 3500, Krems, Austria; Brandenburg Medical School Theodor Fontane, Center for Health Services Research, Seebad 82, 15562, Rüdersdorf b, Berlin, GermanyCenter for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstraße 124, 3500, Krems, Austria; Corresponding author.Introduction: The Dental Apical Inflammation Score (DAIS) is a semi-quantitative histopathological score used to categorise apical inflammatory lesions. This score has shown clinical potential for assessment of wound-healing and infection risk in post-apical lesions. Objective: This retrospective study aimed to investigate whether periapical lesion volume measurements obtained using manual segmentation on cone-beam computed tomography (CBCT) scans were related to the DAIS categorisation. In addition, the correlations of periapical lesion volume with treatment, anatomical sites, and histological diagnosis criteria were explored. Material and methods: CBCT scans and histopathological findings of specimens from a cohort of 153 patients were used in this study. Volumetric measurement of the apical lesions was performed using MeVisLab© software. Fisher's exact test and Kruskal–Wallis H-test were performed to examine the relationship between lesion volume and different factors. Results: Lesions with a DAIS of 4 showed a significantly larger mean volume than those with a DAIS of 2 (p-value of 0.0377). Lesion volumes also showed a significant difference (p-value of 0.0157) in relation to the histological diagnosis types, with diagnosis based on the presence of radicular cysts being associated with a larger mean lesion volume than that based on the proportion of radicular cysts. Discussion/conclusions: The volume of the preoperative periapical lesion correlates with both the DAIS category and histological diagnosis and can be used to assess inflammatory infiltrations, facilitating clinical decision-making and treatment-plan optimisation.http://www.sciencedirect.com/science/article/pii/S2667147624000323Dental apical inflammation scorePeriapical lesionsCone-beam computed tomographyVolumetric measurements |
| spellingShingle | Pascal Grün Sepideh Hatamikia Ruva Jadadic Arb Gjergjindreaj Lars Jansen Florian Pfaffeneder-Mantai Sebastian Fitzek Margit Mostegel Kyung-Eun Anna Choi Dritan Turhani Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score Advances in Oral and Maxillofacial Surgery Dental apical inflammation score Periapical lesions Cone-beam computed tomography Volumetric measurements |
| title | Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| title_full | Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| title_fullStr | Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| title_full_unstemmed | Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| title_short | Volumetric measurements from manually drawn segmentations of periapical lesions in cone-beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| title_sort | volumetric measurements from manually drawn segmentations of periapical lesions in cone beam computed tomography scans correlate with the inflammatory activity classified using the dental apical inflammation score |
| topic | Dental apical inflammation score Periapical lesions Cone-beam computed tomography Volumetric measurements |
| url | http://www.sciencedirect.com/science/article/pii/S2667147624000323 |
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