Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study
Abstract Purpose Ovarian cancer is the most common cause of gynecologic cancer-related deaths. We aimed to assess the global, regional, and national burdens and trends of Ovarian Cancer in Women Aged 45 + from 1990 to 2019 and Projections for 2050, utilizing data from the most recent Global Burden o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-08-01
|
| Series: | Journal of Cancer Research and Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00432-025-06277-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238095533178880 |
|---|---|
| author | Yanan Ren Ren Xu Yazhuo Wang LuYang Su Jianzhi Su |
| author_facet | Yanan Ren Ren Xu Yazhuo Wang LuYang Su Jianzhi Su |
| author_sort | Yanan Ren |
| collection | DOAJ |
| description | Abstract Purpose Ovarian cancer is the most common cause of gynecologic cancer-related deaths. We aimed to assess the global, regional, and national burdens and trends of Ovarian Cancer in Women Aged 45 + from 1990 to 2019 and Projections for 2050, utilizing data from the most recent Global Burden of Disease (GBD) 2021 database. Methods Age-standardized rates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were analyzed using GBD 2021 data. Temporal trends were assessed using estimated annual percentage change (EAPC). Regional disparities were examined via the Socio-Demographic Index (SDI). Age-Period-Cohort (APC) models assessed disease dynamics, while Bayesian APC (BAPC) modeling projected trends to 2050. Results In 2021, global ovarian cancer incidence, prevalence, mortality, and DALYs in women aged 45 + were 239,682; 843,405; 171,246; and 4,352,539, respectively. The global burden declined significantly from 1990 to 2021 and is projected to remain stable through 2050. However, regional disparities persist: High and High-middle SDI regions saw decreases, while Middle to Low SDI regions experienced increases. Burden increased with SDI up to 0.8, then declined. Population growth was the primary contributor, followed by epidemiologic transitions and aging. The 55–59 age group showed the highest morbidity and DALYs; mortality peaked at 65–69 years. Conclusions Although the overall burden of ovarian cancer in women aged 45 + is declining globally, marked regional disparities underscore the need for tailored prevention and treatment strategies to further reduce disease impact and improve outcomes. |
| format | Article |
| id | doaj-art-7022825edcd64b918c7ae583e8f69a0c |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-7022825edcd64b918c7ae583e8f69a0c2025-08-20T04:01:46ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-08-01151811510.1007/s00432-025-06277-9Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease studyYanan Ren0Ren Xu1Yazhuo Wang2LuYang Su3Jianzhi Su4Department of Obstetrics and Gynecology, Hebei General HospitalDepartment of Obstetrics and Gynecology, Hebei General HospitalDepartment of Obstetrics and Gynecology, Hebei General HospitalPhysical Examination Center, Hebei General HospitalDepartment of Urology Surgery, The Fourth Hospital of Hebei Medical UniversityAbstract Purpose Ovarian cancer is the most common cause of gynecologic cancer-related deaths. We aimed to assess the global, regional, and national burdens and trends of Ovarian Cancer in Women Aged 45 + from 1990 to 2019 and Projections for 2050, utilizing data from the most recent Global Burden of Disease (GBD) 2021 database. Methods Age-standardized rates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were analyzed using GBD 2021 data. Temporal trends were assessed using estimated annual percentage change (EAPC). Regional disparities were examined via the Socio-Demographic Index (SDI). Age-Period-Cohort (APC) models assessed disease dynamics, while Bayesian APC (BAPC) modeling projected trends to 2050. Results In 2021, global ovarian cancer incidence, prevalence, mortality, and DALYs in women aged 45 + were 239,682; 843,405; 171,246; and 4,352,539, respectively. The global burden declined significantly from 1990 to 2021 and is projected to remain stable through 2050. However, regional disparities persist: High and High-middle SDI regions saw decreases, while Middle to Low SDI regions experienced increases. Burden increased with SDI up to 0.8, then declined. Population growth was the primary contributor, followed by epidemiologic transitions and aging. The 55–59 age group showed the highest morbidity and DALYs; mortality peaked at 65–69 years. Conclusions Although the overall burden of ovarian cancer in women aged 45 + is declining globally, marked regional disparities underscore the need for tailored prevention and treatment strategies to further reduce disease impact and improve outcomes.https://doi.org/10.1007/s00432-025-06277-9Ovarian cancerGlobal burden of diseaseSocio-demographic indexAge-period-cohort modelBayesian age-period-cohort projectionsIncidence |
| spellingShingle | Yanan Ren Ren Xu Yazhuo Wang LuYang Su Jianzhi Su Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study Journal of Cancer Research and Clinical Oncology Ovarian cancer Global burden of disease Socio-demographic index Age-period-cohort model Bayesian age-period-cohort projections Incidence |
| title | Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study |
| title_full | Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study |
| title_fullStr | Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study |
| title_full_unstemmed | Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study |
| title_short | Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study |
| title_sort | global regional and national burden of ovarian cancer in women aged 45 from 1990 to 2021 and projections for 2050 a systematic analysis based on the 2021 global burden of disease study |
| topic | Ovarian cancer Global burden of disease Socio-demographic index Age-period-cohort model Bayesian age-period-cohort projections Incidence |
| url | https://doi.org/10.1007/s00432-025-06277-9 |
| work_keys_str_mv | AT yananren globalregionalandnationalburdenofovariancancerinwomenaged45from1990to2021andprojectionsfor2050asystematicanalysisbasedonthe2021globalburdenofdiseasestudy AT renxu globalregionalandnationalburdenofovariancancerinwomenaged45from1990to2021andprojectionsfor2050asystematicanalysisbasedonthe2021globalburdenofdiseasestudy AT yazhuowang globalregionalandnationalburdenofovariancancerinwomenaged45from1990to2021andprojectionsfor2050asystematicanalysisbasedonthe2021globalburdenofdiseasestudy AT luyangsu globalregionalandnationalburdenofovariancancerinwomenaged45from1990to2021andprojectionsfor2050asystematicanalysisbasedonthe2021globalburdenofdiseasestudy AT jianzhisu globalregionalandnationalburdenofovariancancerinwomenaged45from1990to2021andprojectionsfor2050asystematicanalysisbasedonthe2021globalburdenofdiseasestudy |