Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis
Abstract Background Circular RNAs are stable non-coding RNAs that regulate biological processes via sponging microRNAs, interacting with RNA binding proteins, as well as controlling gene expression. In ulcerative colitis (UC), hsa_circ_0004104 may worsen inflammation and disrupt immune responses by...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-06-01
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| Series: | The Egyptian Journal of Internal Medicine |
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| Online Access: | https://doi.org/10.1186/s43162-025-00469-y |
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| author | Roaa Tarek Elbannan Hannan Kamal Abdelaziz Eman Ahmed Shaat AM Ibrahim Hend A. yassin |
| author_facet | Roaa Tarek Elbannan Hannan Kamal Abdelaziz Eman Ahmed Shaat AM Ibrahim Hend A. yassin |
| author_sort | Roaa Tarek Elbannan |
| collection | DOAJ |
| description | Abstract Background Circular RNAs are stable non-coding RNAs that regulate biological processes via sponging microRNAs, interacting with RNA binding proteins, as well as controlling gene expression. In ulcerative colitis (UC), hsa_circ_0004104 may worsen inflammation and disrupt immune responses by affecting the JAK/STAT pathway and compromising epithelial barrier integrity. Subjects and methods The present study included 50 patients with UC and 25 healthy subjects as controls. The relative expression of hsa_circ_0004104 was analyzed using real-time quantitative polymerase chain reaction (qPCR), while the concentration of circulating Janus kinase 2 was determined using enzyme-linked immunosorbent assay (ELISA). Results hsa_circ_0004104 was significantly upregulated in active and inactive UC in contrast to control group. In addition, the active UC patients gave a significantly elevated JAK2 level in contrast to inactive and control groups. Furthermore, there was a potent positive correlation relating hsa_circ_0004104 to JAK2 expression in active UC patients. Conclusion Higher levels of hsa_circ_0004104 and JAK2 expression in active UC patients suggest their role in disease activity and their potential use as therapeutic targets and diagnostic biomarkers for UC management. |
| format | Article |
| id | doaj-art-70209eca491a49c4ba78d331c9fa8abd |
| institution | OA Journals |
| issn | 2090-9098 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Internal Medicine |
| spelling | doaj-art-70209eca491a49c4ba78d331c9fa8abd2025-08-20T02:05:42ZengSpringerOpenThe Egyptian Journal of Internal Medicine2090-90982025-06-013711910.1186/s43162-025-00469-yCircular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitisRoaa Tarek Elbannan0Hannan Kamal Abdelaziz1Eman Ahmed Shaat2AM Ibrahim3Hend A. yassin4Department of Medical Biochemistry, Faculty of Medicine, Alexandria UniversityDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria UniversityDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria UniversityDepartment of Internal Medicine (Gastroenterolgy Unit), Faculty of Medicine, Alexandria UniversityDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria UniversityAbstract Background Circular RNAs are stable non-coding RNAs that regulate biological processes via sponging microRNAs, interacting with RNA binding proteins, as well as controlling gene expression. In ulcerative colitis (UC), hsa_circ_0004104 may worsen inflammation and disrupt immune responses by affecting the JAK/STAT pathway and compromising epithelial barrier integrity. Subjects and methods The present study included 50 patients with UC and 25 healthy subjects as controls. The relative expression of hsa_circ_0004104 was analyzed using real-time quantitative polymerase chain reaction (qPCR), while the concentration of circulating Janus kinase 2 was determined using enzyme-linked immunosorbent assay (ELISA). Results hsa_circ_0004104 was significantly upregulated in active and inactive UC in contrast to control group. In addition, the active UC patients gave a significantly elevated JAK2 level in contrast to inactive and control groups. Furthermore, there was a potent positive correlation relating hsa_circ_0004104 to JAK2 expression in active UC patients. Conclusion Higher levels of hsa_circ_0004104 and JAK2 expression in active UC patients suggest their role in disease activity and their potential use as therapeutic targets and diagnostic biomarkers for UC management.https://doi.org/10.1186/s43162-025-00469-yHsa_circ_0004104Circular RNAUlcerative colitisJAK2 |
| spellingShingle | Roaa Tarek Elbannan Hannan Kamal Abdelaziz Eman Ahmed Shaat AM Ibrahim Hend A. yassin Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis The Egyptian Journal of Internal Medicine Hsa_circ_0004104 Circular RNA Ulcerative colitis JAK2 |
| title | Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis |
| title_full | Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis |
| title_fullStr | Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis |
| title_full_unstemmed | Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis |
| title_short | Circular ribonucleic acid 0004104 as a potential biomarker and its relation to Janus kinase 2 in ulcerative colitis |
| title_sort | circular ribonucleic acid 0004104 as a potential biomarker and its relation to janus kinase 2 in ulcerative colitis |
| topic | Hsa_circ_0004104 Circular RNA Ulcerative colitis JAK2 |
| url | https://doi.org/10.1186/s43162-025-00469-y |
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