Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, and targeted therapies. This approach harnesses t...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01897-6 |
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| _version_ | 1823861813402402816 |
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| author | JinSong Li GuanBo Zhang Gang Li Jie Zhang Zhi Yang Lin Yang ShiJie Jiang JiaXing Wang |
| author_facet | JinSong Li GuanBo Zhang Gang Li Jie Zhang Zhi Yang Lin Yang ShiJie Jiang JiaXing Wang |
| author_sort | JinSong Li |
| collection | DOAJ |
| description | Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, and targeted therapies. This approach harnesses the body's immune system to target and eliminate cancer cells, potentially resulting in durable antitumor responses. However, acquired resistance and the tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. Recently, advancements in nanotechnology, coupled with a deeper understanding of cancer biology and nano-biological interactions, have led to the development of various nanoparticles aimed at enhancing therapeutic efficacy through specific targeting of tumor tissues. These nanoparticles increase the accumulation of immunotherapeutic drugs within the tumor microenvironment, thereby transforming the TIME. In this review, we provide a concise overview of the fundamental principles governing the TIME landscape in HCC and discuss the rationale for and applications of nanoparticles in this context. Additionally, we highlight existing challenges and potential opportunities for the clinical translation of cancer nanomedicines. |
| format | Article |
| id | doaj-art-701a74af2df3449a90c0f3c65e9358b8 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-701a74af2df3449a90c0f3c65e9358b82025-02-09T12:43:30ZengSpringerDiscover Oncology2730-60112025-02-0116111610.1007/s12672-025-01897-6Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinomaJinSong Li0GuanBo Zhang1Gang Li2Jie Zhang3Zhi Yang4Lin Yang5ShiJie Jiang6JiaXing Wang7Department of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalDepartment of Hepatobiliary Vascular Surgery, Chengdu Seventh People’s HospitalAbstract Hepatocellular carcinoma (HCC) is one of the most prevalent cancers, characterized by high morbidity and mortality rates. Recently, immunotherapy has emerged as a crucial treatment modality for HCC, following surgery, locoregional therapies, and targeted therapies. This approach harnesses the body's immune system to target and eliminate cancer cells, potentially resulting in durable antitumor responses. However, acquired resistance and the tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. Recently, advancements in nanotechnology, coupled with a deeper understanding of cancer biology and nano-biological interactions, have led to the development of various nanoparticles aimed at enhancing therapeutic efficacy through specific targeting of tumor tissues. These nanoparticles increase the accumulation of immunotherapeutic drugs within the tumor microenvironment, thereby transforming the TIME. In this review, we provide a concise overview of the fundamental principles governing the TIME landscape in HCC and discuss the rationale for and applications of nanoparticles in this context. Additionally, we highlight existing challenges and potential opportunities for the clinical translation of cancer nanomedicines.https://doi.org/10.1007/s12672-025-01897-6NanoparticlesHepatocellular carcinomaImmune microenvironmentImmunotherapyPrecision medicine |
| spellingShingle | JinSong Li GuanBo Zhang Gang Li Jie Zhang Zhi Yang Lin Yang ShiJie Jiang JiaXing Wang Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma Discover Oncology Nanoparticles Hepatocellular carcinoma Immune microenvironment Immunotherapy Precision medicine |
| title | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| title_full | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| title_fullStr | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| title_full_unstemmed | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| title_short | Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| title_sort | harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma |
| topic | Nanoparticles Hepatocellular carcinoma Immune microenvironment Immunotherapy Precision medicine |
| url | https://doi.org/10.1007/s12672-025-01897-6 |
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