Curbing Inflammation in the Ischemic Heart Disease
A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocard...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/183061 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849413831390920704 |
|---|---|
| author | Paulo Roberto B. Evora Julio Nather Paulo Victor Tubino Agnes Afrodite S. Albuquerque Andrea Carla Celotto Alfredo J. Rodrigues |
| author_facet | Paulo Roberto B. Evora Julio Nather Paulo Victor Tubino Agnes Afrodite S. Albuquerque Andrea Carla Celotto Alfredo J. Rodrigues |
| author_sort | Paulo Roberto B. Evora |
| collection | DOAJ |
| description | A modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process. |
| format | Article |
| id | doaj-art-70136b0d49f04355aa208d7018e996a2 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-70136b0d49f04355aa208d7018e996a22025-08-20T03:34:01ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/183061183061Curbing Inflammation in the Ischemic Heart DiseasePaulo Roberto B. Evora0Julio Nather1Paulo Victor Tubino2Agnes Afrodite S. Albuquerque3Andrea Carla Celotto4Alfredo J. Rodrigues5Department of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilDepartment of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilDepartment of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilDepartment of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilDepartment of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilDepartment of Surgery and Anatomy, Ribeirão Preto Faculty of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, BrazilA modern concept considers acute coronary syndrome as an autoinflammatory disorder. From the onset to the healing stage, an endless inflammation has been presented with complex, multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Inflammatory response following acute myocardial infarction has been well documented since the 1940s and 1950s, including increased erythrocyte sedimentation rate, the C-reactive protein analysis, and the determination of serum complement. It is surprising to note, based on a wide literature overview including the following 30 years (decades of 1960, 1970, and 1980), that the inflammatory acute myocardium infarction lost its focus, virtually disappearing from the literature reports. The reversal of this historical process occurs in the 1990s with the explosion of studies involving cytokines. Considering the importance of inflammation in the pathophysiology of ischemic heart disease, the aim of this paper is to present a conceptual overview in order to explore the possibility of curbing this inflammatory process.http://dx.doi.org/10.1155/2013/183061 |
| spellingShingle | Paulo Roberto B. Evora Julio Nather Paulo Victor Tubino Agnes Afrodite S. Albuquerque Andrea Carla Celotto Alfredo J. Rodrigues Curbing Inflammation in the Ischemic Heart Disease International Journal of Inflammation |
| title | Curbing Inflammation in the Ischemic Heart Disease |
| title_full | Curbing Inflammation in the Ischemic Heart Disease |
| title_fullStr | Curbing Inflammation in the Ischemic Heart Disease |
| title_full_unstemmed | Curbing Inflammation in the Ischemic Heart Disease |
| title_short | Curbing Inflammation in the Ischemic Heart Disease |
| title_sort | curbing inflammation in the ischemic heart disease |
| url | http://dx.doi.org/10.1155/2013/183061 |
| work_keys_str_mv | AT paulorobertobevora curbinginflammationintheischemicheartdisease AT julionather curbinginflammationintheischemicheartdisease AT paulovictortubino curbinginflammationintheischemicheartdisease AT agnesafroditesalbuquerque curbinginflammationintheischemicheartdisease AT andreacarlacelotto curbinginflammationintheischemicheartdisease AT alfredojrodrigues curbinginflammationintheischemicheartdisease |