Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.

Bacteria produce a plethora of natural products that are in clinical, agricultural and biotechnological use. Genome mining has uncovered millions of biosynthetic gene clusters (BGCs) that encode their biosynthesis, the vast majority of them lacking a clear product or function. Thus, a major challeng...

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Bibliographic Details
Main Authors: Hannah E Augustijn, Zachary L Reitz, Le Zhang, Jeanine A Boot, Somayah S Elsayed, Gregory L Challis, Marnix H Medema, Gilles P van Wezel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003183
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