Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria
This study evaluated the eco-health risk associated with exposure to lead (Pb) in mining sites in Benue State, Nigeria. Lead contamination was assessed in 48 water samples and 40 human blood samples. An Atomic Absorption Spectrophotometer was used for Pb analysis and ELISA kits for tumor necrosis fa...
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MDPI AG
2024-02-01
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| author | Samuel N. Paul Chiara Frazzoli Orish E. Orisakwe |
| author_facet | Samuel N. Paul Chiara Frazzoli Orish E. Orisakwe |
| author_sort | Samuel N. Paul |
| collection | DOAJ |
| description | This study evaluated the eco-health risk associated with exposure to lead (Pb) in mining sites in Benue State, Nigeria. Lead contamination was assessed in 48 water samples and 40 human blood samples. An Atomic Absorption Spectrophotometer was used for Pb analysis and ELISA kits for tumor necrosis factor-alpha (TNF-α) and kidney injury molecule-1 (KIM-1) analysis. A correlation was found between the blood Pb level (BLL) and the upregulation of KIM-1. The BLL of females was slightly higher than males, resulting in a higher inflammatory response through increased TNF-α levels. An increased inflammatory response due to chronic Pb exposure was observed with age. Miners and farmers around the mining sites recorded higher TNF-α levels compared to businesspeople, thus suggesting direct exposure to other mining-associated contaminants. Artisanal and informal mining impact environmental health and the Pb body burden. |
| format | Article |
| id | doaj-art-700ba9758d284a7e80ee3dbe8e29eafe |
| institution | DOAJ |
| issn | 2673-9992 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences Forum |
| spelling | doaj-art-700ba9758d284a7e80ee3dbe8e29eafe2025-08-20T02:43:53ZengMDPI AGMedical Sciences Forum2673-99922024-02-01251210.3390/msf2024025002Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, NigeriaSamuel N. Paul0Chiara Frazzoli1Orish E. Orisakwe2World Bank African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Choba, Port Harcourt 5323, NigeriaDepartment of Cardiovascular and Endocrine-Metabolic Diseases and Ageing, Istituto Superiore di Sanità, Via Giano della Bella 34, 00162 Rome, ItalyWorld Bank African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, Choba, Port Harcourt 5323, NigeriaThis study evaluated the eco-health risk associated with exposure to lead (Pb) in mining sites in Benue State, Nigeria. Lead contamination was assessed in 48 water samples and 40 human blood samples. An Atomic Absorption Spectrophotometer was used for Pb analysis and ELISA kits for tumor necrosis factor-alpha (TNF-α) and kidney injury molecule-1 (KIM-1) analysis. A correlation was found between the blood Pb level (BLL) and the upregulation of KIM-1. The BLL of females was slightly higher than males, resulting in a higher inflammatory response through increased TNF-α levels. An increased inflammatory response due to chronic Pb exposure was observed with age. Miners and farmers around the mining sites recorded higher TNF-α levels compared to businesspeople, thus suggesting direct exposure to other mining-associated contaminants. Artisanal and informal mining impact environmental health and the Pb body burden.https://www.mdpi.com/2673-9992/25/1/2watereco-healthblood lead leveltoxicologyOne Health |
| spellingShingle | Samuel N. Paul Chiara Frazzoli Orish E. Orisakwe Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria Medical Sciences Forum water eco-health blood lead level toxicology One Health |
| title | Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria |
| title_full | Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria |
| title_fullStr | Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria |
| title_full_unstemmed | Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria |
| title_short | Towards a One Health Assessment of Artisanal and Informal Mining in Benue State, Nigeria |
| title_sort | towards a one health assessment of artisanal and informal mining in benue state nigeria |
| topic | water eco-health blood lead level toxicology One Health |
| url | https://www.mdpi.com/2673-9992/25/1/2 |
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