Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir

Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir

Amorphous salt solid dispersion (ASSD) of Dolutegravir amorphous salt (DSSD) was generated using quench cooling and compared to its Dolutegravir free acid solid dispersion (DFSD) to improve the solubility and bioavailability. Soluplus (SLP) was used as a polymeric carrier in both solid dispersions....

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Bibliographic Details
Main Authors:	Dani Lakshman Yarlagadda, Akshatha M. Nayak, Bheemisetty Brahmam, Krishnamurthy Bhat
Format:	Article
Language:	English
Published:	Wiley 2023-01-01
Series:	Advances in Pharmacological and Pharmaceutical Sciences
Online Access:	http://dx.doi.org/10.1155/2023/7198674
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