Effect of osthole on inflammatory responses of mice with primary sjögren's syndrome
We aimed to assess the effect of osthole on the inflammatory responses of mice suffering from primary Sjögren's syndrome (PSS). Fifty naive non‐obese diabetic (NOD/Ltj) mice were included to establish a spontaneous model of PSS and assigned into a control group, a 20 mg/kg osthole group, a 30 m...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2024-08-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3133 |
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| Summary: | We aimed to assess the effect of osthole on the inflammatory responses of mice suffering
from primary Sjögren's syndrome (PSS). Fifty naive non‐obese diabetic (NOD/Ltj) mice
were included to establish a spontaneous model of PSS and assigned into a control group,
a 20 mg/kg osthole group, a 30 mg/kg osthole group, a 40 mg/kg osthole group and a
50 mg/kg osthole group in a random manner. Osthole (20, 30, 40, and 50 mg/kg, once
a day) together with normal saline (every day) in an equal volume were injected into
osthole treatment groups and control group, respectively. Compared with the control
group, the inflammatory cells in salivary gland tissues of NOD/Ltj mice manifested
gradually ameliorated infiltration, the destruction of acinar cells was relieved gradually
(P<0.05). In comparison to those obtained from the control group, the inflammatory
factors IFN-α, IFN-β, IL-6, IL-8 and TNF-α as well as the GMP-AMP synthase (cGAS)
and stimulator of interferon genes (STING) in salivary gland tissues of NOD/Ltj mice
declined gradually at the expression level as the osthole concentration augmented,
showing statistically significant differences (P<0.05). Osthole is capable of mitigating
inflammatory responses of PSS mice by impeding the cGAS-STING signaling pathway. |
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| ISSN: | 1309-2251 |