Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

IntroductionThe biphasic dose-response behavior, also known as hormesis, is a characteristic feature of numerous natural products. It is defined by beneficial effects at low concentrations and toxicity at higher doses. This study investigates the hormetic effects of Brosimine B, a flavonoid derived...

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Bibliographic Details
Main Authors:	Susanne Suely Santos Fonseca, Natacha M. S. Port’s, Gisele Priscila Soares Aguiar, Eliã P. Botelho, Nádia M. G. Couto, Wandson Braamcamp Souza Pinheiro, André Salim Khayat, Elizabeth S. Yamada, Edmar T. Costa, Chubert Bernardo C. Sena, Mara Silvia P. Arruda, Carlomagno P. Bahia, Antonio Pereira
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	oxidative stress Brosimine b retinal cell neuroprotection hormesis natural products
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1558726/full
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Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

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