Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

Brosimine B and the biphasic dose-response: insights into hormesis and retinal neuroprotection

IntroductionThe biphasic dose-response behavior, also known as hormesis, is a characteristic feature of numerous natural products. It is defined by beneficial effects at low concentrations and toxicity at higher doses. This study investigates the hormetic effects of Brosimine B, a flavonoid derived...

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Main Authors: Susanne Suely Santos Fonseca, Natacha M. S. Port’s, Gisele Priscila Soares Aguiar, Eliã P. Botelho, Nádia M. G. Couto, Wandson Braamcamp Souza Pinheiro, André Salim Khayat, Elizabeth S. Yamada, Edmar T. Costa, Chubert Bernardo C. Sena, Mara Silvia P. Arruda, Carlomagno P. Bahia, Antonio Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
oxidative stress
Brosimine b
retinal cell
neuroprotection
hormesis
natural products
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1558726/full
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