DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

DC-SIGN increases the affinity of HIV-1 envelope glycoprotein interaction with CD4.

Mannose-binding C-type lectin receptors, expressed on Langerhans cells and subepithelial dendritic cells (DCs) of cervico-vaginal tissues, play an important role in HIV-1 capture and subsequent dissemination to lymph nodes. DC-SIGN has been implicated in both productive infection of DCs and the DC-m...

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Main Authors: Karolin Hijazi, Yufei Wang, Carlo Scala, Simon Jeffs, Colin Longstaff, Daniel Stieh, Beth Haggarty, Guido Vanham, Dominique Schols, Jan Balzarini, Ian M Jones, James Hoxie, Robin Shattock, Charles G Kelly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028307&type=printable
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