Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint
Currently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/318 |
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| author | J. V. Kotsiubinskaya |
| author_facet | J. V. Kotsiubinskaya |
| author_sort | J. V. Kotsiubinskaya |
| collection | DOAJ |
| description | Currently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation of the disease. In the framework of the biopsychosocial concept, a hypothesis has been formulated about the importance of the polymorphism of the COMT and ADRB-2 genes for the development of SDJ TMJs, which make these individuals “vulnerable” to the development of chronic pain syndromes. It was found that a decrease in COMT activity leads to an increase in the level of catecholamimes, in particular, such as adrenaline, which contribute to the formation of persistent pain states by stimulating β2-adrenergic receptors in the peripheral and central nervous system. |
| format | Article |
| id | doaj-art-6ffdb892ec544f1093ae0fe5b161fd22 |
| institution | DOAJ |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-6ffdb892ec544f1093ae0fe5b161fd222025-08-20T03:20:22ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2019-12-0104-1889010.31363/2313-7053-2019-4-1-88-90297Genetic risk factors of syndrome pain dysfunction of the temporomandibular jointJ. V. Kotsiubinskaya0Federal State Institution «V. M. Bekhterev National Research Medical Center for Psychiatry and Neurology» of the Russian Federation Ministry of HealthCurrently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation of the disease. In the framework of the biopsychosocial concept, a hypothesis has been formulated about the importance of the polymorphism of the COMT and ADRB-2 genes for the development of SDJ TMJs, which make these individuals “vulnerable” to the development of chronic pain syndromes. It was found that a decrease in COMT activity leads to an increase in the level of catecholamimes, in particular, such as adrenaline, which contribute to the formation of persistent pain states by stimulating β2-adrenergic receptors in the peripheral and central nervous system.https://www.bekhterevreview.com/jour/article/view/318pain dysfunction syndrome, temporomandibular joint, somatoform disorder, catechol-omethyltransferase, beta-2-adrenergic receptor |
| spellingShingle | J. V. Kotsiubinskaya Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева pain dysfunction syndrome, temporomandibular joint, somatoform disorder, catechol-omethyltransferase, beta-2-adrenergic receptor |
| title | Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| title_full | Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| title_fullStr | Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| title_full_unstemmed | Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| title_short | Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| title_sort | genetic risk factors of syndrome pain dysfunction of the temporomandibular joint |
| topic | pain dysfunction syndrome, temporomandibular joint, somatoform disorder, catechol-omethyltransferase, beta-2-adrenergic receptor |
| url | https://www.bekhterevreview.com/jour/article/view/318 |
| work_keys_str_mv | AT jvkotsiubinskaya geneticriskfactorsofsyndromepaindysfunctionofthetemporomandibularjoint |