Genetic risk factors of syndrome pain dysfunction of the temporomandibular joint
Currently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation...
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| Main Author: | |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2019-12-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| Subjects: | |
| Online Access: | https://www.bekhterevreview.com/jour/article/view/318 |
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| Summary: | Currently, the syndrome of pain dysfunction of the temporomandibular joint is not considered exclusively a local disorder, but rather is considered as a clinical outcome of the combined effect of many factors (local and systemic), which act simultaneously and determine, ultimately, the manifestation of the disease. In the framework of the biopsychosocial concept, a hypothesis has been formulated about the importance of the polymorphism of the COMT and ADRB-2 genes for the development of SDJ TMJs, which make these individuals “vulnerable” to the development of chronic pain syndromes. It was found that a decrease in COMT activity leads to an increase in the level of catecholamimes, in particular, such as adrenaline, which contribute to the formation of persistent pain states by stimulating β2-adrenergic receptors in the peripheral and central nervous system. |
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| ISSN: | 2313-7053 2713-055X |