Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome

Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome

Abstract Background Transforming Growth Factor (TGF) and Bone Morphogenetic Protein (BMP) signalling critically influence pancreatic ductal adenocarcinoma (PDAC) progression, with TGF-B paradoxically exerting both tumour-promoting and -suppressive effects. Parallel to this observation, the specific...

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Bibliographic Details
Main Authors: Konstantin Bräutigam, Philipp Zens, Stefan Reinhard, Jessica L. Rohrbach, Simon J. Leedham, Anna S. Wenning, Beat Gloor, Viktor H. Koelzer, Martin Wartenberg
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Transforming growth factors
Bone morphogenetic proteins
Stromal cells
Pancreatic neoplasms
AI (Artificial intelligence)
GREM1 protein
Online Access:https://doi.org/10.1186/s12885-025-14751-3
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