Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019
Aims: Very early-onset colorectal cancer (EOCRC) was defined as CRC diagnosed before the age of 35 proposed by the latest EOCRC management guideline. Until now, the disease burden of very EOCRC has never been reported. This study aimed to explore the burden of very EOCRC across the past three decade...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558624001556 |
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| author | Zhen Junhai Meng Yang Tan Zongbiao Yan Wenxuan Li Tiange Wu Yanrui Liu Chuan Dong Weiguo |
| author_facet | Zhen Junhai Meng Yang Tan Zongbiao Yan Wenxuan Li Tiange Wu Yanrui Liu Chuan Dong Weiguo |
| author_sort | Zhen Junhai |
| collection | DOAJ |
| description | Aims: Very early-onset colorectal cancer (EOCRC) was defined as CRC diagnosed before the age of 35 proposed by the latest EOCRC management guideline. Until now, the disease burden of very EOCRC has never been reported. This study aimed to explore the burden of very EOCRC across the past three decades. Methods: We extracted the data from Global Burden of Disease Study to analyze the disease burden of very EOCRC. Risk factors for the burden of deaths and disability-adjusted life years (DALYs) due to very EOCRC were also explored in this study. Additionally, decomposition analysis and frontier analysis were also conducted. Results: Despite regional and gender variations, the global very EOCRC incidence cases increased from 21,874 (95 % UI: 20,386-23,470) to 41,545 (95 % UI: 37,978-45,523). Besides, the deaths cases also increased from 11,445 (95 % UI: 10,545-12,374) to 15,486 (95 % UI: 14,289-16,803), and the DALYs cases increased from 718,136 (95 % UI: 659,858-778,283) to 961,460 (95 % UI: 886,807-1,042,734). Decomposition analysis revealed the epidemiological change contributed most to the incidence burden of very EOCRC. Countries or regions with Sociodemographic Index (SDI) between 0.4 and 0.8 had greater disease burden improvement potential through frontier analysis. Diet low in milk, diet low in calcium, alcohol use, and high body-mass index were the main contributors to deaths and DALYs. Conclusions: The increase in CRC burden among populations younger than 35 years globally requires vigilance from policy makers, physicians, and young individuals themselves, especially those regions experiencing faster growth burden of very EOCRC. |
| format | Article |
| id | doaj-art-6ffbc365c4df49f995e080715ddc466d |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-6ffbc365c4df49f995e080715ddc466d2025-02-03T04:16:35ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-02-0160101114Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019Zhen Junhai0Meng Yang1Tan Zongbiao2Yan Wenxuan3Li Tiange4Wu Yanrui5Liu Chuan6Dong Weiguo7Department of General Practice, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of General Practice, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, China; Corresponding author at: Department of Gastroenterology, Renmin Hospital of Wuhan University, 99 Zhangzhidong Road, Wuhan, 430060, Hubei Province, China.Aims: Very early-onset colorectal cancer (EOCRC) was defined as CRC diagnosed before the age of 35 proposed by the latest EOCRC management guideline. Until now, the disease burden of very EOCRC has never been reported. This study aimed to explore the burden of very EOCRC across the past three decades. Methods: We extracted the data from Global Burden of Disease Study to analyze the disease burden of very EOCRC. Risk factors for the burden of deaths and disability-adjusted life years (DALYs) due to very EOCRC were also explored in this study. Additionally, decomposition analysis and frontier analysis were also conducted. Results: Despite regional and gender variations, the global very EOCRC incidence cases increased from 21,874 (95 % UI: 20,386-23,470) to 41,545 (95 % UI: 37,978-45,523). Besides, the deaths cases also increased from 11,445 (95 % UI: 10,545-12,374) to 15,486 (95 % UI: 14,289-16,803), and the DALYs cases increased from 718,136 (95 % UI: 659,858-778,283) to 961,460 (95 % UI: 886,807-1,042,734). Decomposition analysis revealed the epidemiological change contributed most to the incidence burden of very EOCRC. Countries or regions with Sociodemographic Index (SDI) between 0.4 and 0.8 had greater disease burden improvement potential through frontier analysis. Diet low in milk, diet low in calcium, alcohol use, and high body-mass index were the main contributors to deaths and DALYs. Conclusions: The increase in CRC burden among populations younger than 35 years globally requires vigilance from policy makers, physicians, and young individuals themselves, especially those regions experiencing faster growth burden of very EOCRC.http://www.sciencedirect.com/science/article/pii/S1476558624001556Colorectal cancerDisease burdenRisk factor |
| spellingShingle | Zhen Junhai Meng Yang Tan Zongbiao Yan Wenxuan Li Tiange Wu Yanrui Liu Chuan Dong Weiguo Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 Neoplasia: An International Journal for Oncology Research Colorectal cancer Disease burden Risk factor |
| title | Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 |
| title_full | Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 |
| title_fullStr | Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 |
| title_full_unstemmed | Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 |
| title_short | Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 2019 |
| title_sort | global regional and national burden of very early onset colorectal cancer and its risk factors from 1990 to 2019 a systematic analysis for the global burden of disease study 2019 |
| topic | Colorectal cancer Disease burden Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S1476558624001556 |
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