A multi-antigen-based SARS-CoV-2 vaccine provides higher immune responses and protection against SARS-CoV-2 variants

A multi-antigen-based SARS-CoV-2 vaccine provides higher immune responses and protection against SARS-CoV-2 variants

Abstract The emergence of divergent SARS-CoV-2 variants has significantly compromised the effectiveness of first-generation COVID-19 vaccines. We investigated a prime-boost approach using bovine adenoviral (Ad) [BAd] and human Ad (HAd) vectors expressing the spike (S), membrane (M), or nucleocapsid...

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Bibliographic Details
Main Authors: Marwa Alhashimi, Ekramy E. Sayedahmed, Ahmed Elkashif, Shubhada K. Chothe, Wen-Chien Wang, Muralimanohara S. T. Murala, Vivek Gairola, Nobuko Wakamatsu, Abhinay Gontu, Santhamani Ramasamy, Lindsey LaBella, Padmaja Jakka, Meera Surendran Nair, Ruth H. Nissly, Suresh V. Kuchipudi, Suresh K. Mittal
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01198-7
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