Medical imaging-based companion diagnostics for solid tumors
Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients, is b...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
|
| Series: | EngMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950489924000095 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850112347058733056 |
|---|---|
| author | Rui Yin Qingpeng Zhang Shiyi Liao Chang Lu Cheng Zhang Qingyun Cai Guosheng Song |
| author_facet | Rui Yin Qingpeng Zhang Shiyi Liao Chang Lu Cheng Zhang Qingyun Cai Guosheng Song |
| author_sort | Rui Yin |
| collection | DOAJ |
| description | Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients, is becoming more and more important. However, most current US Food and Drug Administration (FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo. Consequently, new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables. They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments. This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx. We believe that this review offers additional details and directions for promoting medical imaging-based CDx development. |
| format | Article |
| id | doaj-art-6fefbba3283c4e4b90d09508251bf554 |
| institution | OA Journals |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-6fefbba3283c4e4b90d09508251bf5542025-08-20T02:37:24ZengElsevierEngMedicine2950-48992024-06-011110000910.1016/j.engmed.2024.100009Medical imaging-based companion diagnostics for solid tumorsRui Yin0Qingpeng Zhang1Shiyi Liao2Chang Lu3Cheng Zhang4Qingyun Cai5Guosheng Song6State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaState Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaCorresponding author.; State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical, Engineering, Hunan University, Changsha 410082, ChinaHeterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), a clinical technique that gives doctors vital biomarker information to enhance patient outcomes through matching specific treatments to patients, is becoming more and more important. However, most current US Food and Drug Administration (FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers in the solid tumor microenvironment because they are used in vitro and ex vivo. Consequently, new medical imaging-based CDx tests have been widely used to detect interpatient and intrapatient tumor heterogeneity to assess the intratumoral distribution of specific biomarkers and microenvironment variables. They provide patient stratification for targeted therapies and the differentiation of patient populations that benefit from alternative treatments. This review provides an overview of the recent advances in medical imaging-based CDx for solid tumors and summarizes the various tumor microenvironment biomarkers utilized in imaging-based CDx. We believe that this review offers additional details and directions for promoting medical imaging-based CDx development.http://www.sciencedirect.com/science/article/pii/S2950489924000095ImagingBiomarkersCompanion diagnosticsSolid tumors |
| spellingShingle | Rui Yin Qingpeng Zhang Shiyi Liao Chang Lu Cheng Zhang Qingyun Cai Guosheng Song Medical imaging-based companion diagnostics for solid tumors EngMedicine Imaging Biomarkers Companion diagnostics Solid tumors |
| title | Medical imaging-based companion diagnostics for solid tumors |
| title_full | Medical imaging-based companion diagnostics for solid tumors |
| title_fullStr | Medical imaging-based companion diagnostics for solid tumors |
| title_full_unstemmed | Medical imaging-based companion diagnostics for solid tumors |
| title_short | Medical imaging-based companion diagnostics for solid tumors |
| title_sort | medical imaging based companion diagnostics for solid tumors |
| topic | Imaging Biomarkers Companion diagnostics Solid tumors |
| url | http://www.sciencedirect.com/science/article/pii/S2950489924000095 |
| work_keys_str_mv | AT ruiyin medicalimagingbasedcompaniondiagnosticsforsolidtumors AT qingpengzhang medicalimagingbasedcompaniondiagnosticsforsolidtumors AT shiyiliao medicalimagingbasedcompaniondiagnosticsforsolidtumors AT changlu medicalimagingbasedcompaniondiagnosticsforsolidtumors AT chengzhang medicalimagingbasedcompaniondiagnosticsforsolidtumors AT qingyuncai medicalimagingbasedcompaniondiagnosticsforsolidtumors AT guoshengsong medicalimagingbasedcompaniondiagnosticsforsolidtumors |