Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report
The occurrence of endotracheal/endobronchial metastasis (EEM) after complete resection of a primary lung cancer is rare. Here, we report the case of an 86‐year‐old woman in whom EEM occurred twice over a 20‐year period following complete resection of a primary adenocarcinoma localized to the left ma...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.13730 |
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| _version_ | 1850034032470917120 |
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| author | Yohei Maki Yoshifumi Kimizuka Hisashi Sasaki Takayuki Yamamoto Chie Watanabe Tomoya Sano Yoichi Tagami Kazuhisa Misawa Jun Miyata Yuji Fujikura Hideyuki Shimazaki Akihiko Kawana |
| author_facet | Yohei Maki Yoshifumi Kimizuka Hisashi Sasaki Takayuki Yamamoto Chie Watanabe Tomoya Sano Yoichi Tagami Kazuhisa Misawa Jun Miyata Yuji Fujikura Hideyuki Shimazaki Akihiko Kawana |
| author_sort | Yohei Maki |
| collection | DOAJ |
| description | The occurrence of endotracheal/endobronchial metastasis (EEM) after complete resection of a primary lung cancer is rare. Here, we report the case of an 86‐year‐old woman in whom EEM occurred twice over a 20‐year period following complete resection of a primary adenocarcinoma localized to the left main bronchus and trachea. The presence of EEM was confirmed by establishing immunohistochemical homology of the metastases with the primary tumor. To the best of our knowledge, this is the first reported case of repetitive EEM of primary lung adenocarcinoma. Lymphatic invasion in the primary lesion suggested that a possible route for EEM was the peripheral lymphatic tract, explaining the slow recurrence rate. We conclude that observation of the trachea/bronchus over a long period post operation could be important in monitoring for EEM, particularly if lymphatic invasion is confirmed in the primary tumor. |
| format | Article |
| id | doaj-art-6fee42d432bc4e4db8bb82b9a06343aa |
| institution | DOAJ |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-6fee42d432bc4e4db8bb82b9a06343aa2025-08-20T02:57:57ZengWileyThoracic Cancer1759-77061759-77142021-01-0112113313610.1111/1759-7714.13730Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case reportYohei Maki0Yoshifumi Kimizuka1Hisashi Sasaki2Takayuki Yamamoto3Chie Watanabe4Tomoya Sano5Yoichi Tagami6Kazuhisa Misawa7Jun Miyata8Yuji Fujikura9Hideyuki Shimazaki10Akihiko Kawana11Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanDepartment of Laboratory Medicine National Defense Medical College Tokorozawa JapanDivision of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine National Defense Medical College Tokorozawa JapanThe occurrence of endotracheal/endobronchial metastasis (EEM) after complete resection of a primary lung cancer is rare. Here, we report the case of an 86‐year‐old woman in whom EEM occurred twice over a 20‐year period following complete resection of a primary adenocarcinoma localized to the left main bronchus and trachea. The presence of EEM was confirmed by establishing immunohistochemical homology of the metastases with the primary tumor. To the best of our knowledge, this is the first reported case of repetitive EEM of primary lung adenocarcinoma. Lymphatic invasion in the primary lesion suggested that a possible route for EEM was the peripheral lymphatic tract, explaining the slow recurrence rate. We conclude that observation of the trachea/bronchus over a long period post operation could be important in monitoring for EEM, particularly if lymphatic invasion is confirmed in the primary tumor.https://doi.org/10.1111/1759-7714.13730Adenocarcinomaendotracheal/endobronchial metastasislung cancerlymphatic metastasispathology |
| spellingShingle | Yohei Maki Yoshifumi Kimizuka Hisashi Sasaki Takayuki Yamamoto Chie Watanabe Tomoya Sano Yoichi Tagami Kazuhisa Misawa Jun Miyata Yuji Fujikura Hideyuki Shimazaki Akihiko Kawana Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report Thoracic Cancer Adenocarcinoma endotracheal/endobronchial metastasis lung cancer lymphatic metastasis pathology |
| title | Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report |
| title_full | Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report |
| title_fullStr | Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report |
| title_full_unstemmed | Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report |
| title_short | Lung adenocarcinoma with repetitive endotracheal/endobronchial metastasis 20 years after surgery: A case report |
| title_sort | lung adenocarcinoma with repetitive endotracheal endobronchial metastasis 20 years after surgery a case report |
| topic | Adenocarcinoma endotracheal/endobronchial metastasis lung cancer lymphatic metastasis pathology |
| url | https://doi.org/10.1111/1759-7714.13730 |
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