Early Postischemic Cerebral Circulatory Disorders and Their Correction with Perftoran
Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.Results: no-reflow was shown to be caused by pial arteriola...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-06-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1144 |
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| Summary: | Objective: to study the conditions and mechanism of postischemic no-reflow and delayed hypoperfusion and to correct them with perfluorane.Materials and methods: Both phenomena were reproduced by using a rat model of global cerebral ischemia.Results: no-reflow was shown to be caused by pial arteriolar collapse that occurred in ischemia and lasted during reperfusion. Delayed postischemic hypoperfusion was induced by increased pial arteriolar tone.Conclusion: Intraarterial injection of perfluorane alleviates the manifestation of both phenomena due to better oxygen supply to ischemic brain tissue and, probably, to calcium channel blockage. |
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| ISSN: | 1813-9779 2411-7110 |