Presepsin as a predictive indicator of severity in Coronavirus disease-2019 (COVID-19)
Coronavirus disease 2019 (COVID-19) currently represents a major health emergency worldwide. Early recognition of severe forms of this virus is essential to align effective management and treatment strategies. Presepsin (PSP), the soluble cluster of differentiation (CD14) subtype; is a useful bio...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2021-08-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_190249_8cda899fc06973445a3bffc2a1ee08fe.pdf |
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| Summary: | Coronavirus disease 2019 (COVID-19) currently represents a major health emergency
worldwide. Early recognition of severe forms of this virus is essential to align effective
management and treatment strategies. Presepsin (PSP), the soluble cluster of differentiation
(CD14) subtype; is a useful biomarker not only for early diagnosis of sepsis but also could be
used as a predictive for the severity and mortality in septic patients, as well as in pneumonia.
This study aimed to investigate the potential utility of PSP as a predictive indicator of disease
severity in COVID-19 patients. A total of 42 COVID-19 patients were enrolled in this study
and stratified into moderate and severe groups, in addition to 15 healthy patients as controls.
The PSP levels were measured using Enzyme Linked Immuno-Sorbent Assay (ELISA) within
24 h (1 day) as well as on the 5th day of admission to the Geriatrics hospital, Ain Shams
University, Cairo, Egypt, in addition to other relevant laboratory tests performed during the
study period from July to October, 2020. Results showed that the PSP levels were significantly
higher in COVID-19 patients compared to the controls (p< 0.001), and were also noticeably
elevated in severe group than in moderate group on the 1st day 1 (p= 0.008) and the 5th day (p=
0.003) of hospital admission. Significant correlation between PSP level and hospital stay (r =
0.332, p= 0.032) was detected; however, no significant correlation was recorded with the
different laboratory parameters. For severity prediction, PSP revealed significant values for the
1
st day and the 5th day (AUC 0.737; p= 0.003 and AUC 0.810; p< 0.001), respectively. Data
obtained in this study suggested the potential utility of PSP as a predictive indicator of severity
in COVID-19 patients, thus allowing for earlier identification of high-risk patients and those
who will be hospitalized for longer periods. |
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| ISSN: | 2537-0286 2537-0294 |