Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern
Potential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3±7.8 years, BMI 33.9±6.6 Kg/m2, and BP 144.2±9.38/88.5±6.03 mmHg. All consumed a control diet for...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/472396 |
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| author | Pao-Hwa Lin Jason D. Allen Yi-Ju Li Miao Yu Lillian F. Lien Laura P. Svetkey |
| author_facet | Pao-Hwa Lin Jason D. Allen Yi-Ju Li Miao Yu Lillian F. Lien Laura P. Svetkey |
| author_sort | Pao-Hwa Lin |
| collection | DOAJ |
| description | Potential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3±7.8 years, BMI 33.9±6.6 Kg/m2, and BP 144.2±9.38/88.5±6.03 mmHg. All consumed a control diet for one week, then were randomized to control or DASH for another two weeks (week one and two). With DASH, but not controls, SBP fell by 10.65±12.89 (𝑃=0.023) and 9.60±11.23 (𝑃=0.039) mmHg and DBP by 5.95±8.01 (𝑃=0.069) and 8.60±9.13 mmHg (𝑃=0.011) at the end of week one and two, respectively. Univariate regressions showed that changes in urinary sodium/potassium ratio (𝛽=1.99) and plasma renin activity (𝛽=−15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all 𝑃<0.05). Plasma nitrite following hyperemia showed a treatment effect (𝑃=0.014) and increased at week two (𝑃=0.001). Pulse wave velocity decreased over time with DASH (trend 𝑃=0.019), and reached significance at week two (𝑃=0.026). This response may be mediated by an improvement in upregulation of nitric oxide bioavailability. Early natriuresis and reductions in oxidative stress cannot be ruled out. Future studies are needed to verify these findings, assess the possibility of earlier effects, and examine other potential mediators. |
| format | Article |
| id | doaj-art-6fe098444fce4967b0811aefb6e47147 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-6fe098444fce4967b0811aefb6e471472025-02-03T06:07:46ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/472396472396Blood Pressure-Lowering Mechanisms of the DASH Dietary PatternPao-Hwa Lin0Jason D. Allen1Yi-Ju Li2Miao Yu3Lillian F. Lien4Laura P. Svetkey5Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USADivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USADepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USADepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USADivision of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USADivision of Nephrology, Department of Medicine, Duke University Medical Center, Durham, NC, 27710, USAPotential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3±7.8 years, BMI 33.9±6.6 Kg/m2, and BP 144.2±9.38/88.5±6.03 mmHg. All consumed a control diet for one week, then were randomized to control or DASH for another two weeks (week one and two). With DASH, but not controls, SBP fell by 10.65±12.89 (𝑃=0.023) and 9.60±11.23 (𝑃=0.039) mmHg and DBP by 5.95±8.01 (𝑃=0.069) and 8.60±9.13 mmHg (𝑃=0.011) at the end of week one and two, respectively. Univariate regressions showed that changes in urinary sodium/potassium ratio (𝛽=1.99) and plasma renin activity (𝛽=−15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all 𝑃<0.05). Plasma nitrite following hyperemia showed a treatment effect (𝑃=0.014) and increased at week two (𝑃=0.001). Pulse wave velocity decreased over time with DASH (trend 𝑃=0.019), and reached significance at week two (𝑃=0.026). This response may be mediated by an improvement in upregulation of nitric oxide bioavailability. Early natriuresis and reductions in oxidative stress cannot be ruled out. Future studies are needed to verify these findings, assess the possibility of earlier effects, and examine other potential mediators.http://dx.doi.org/10.1155/2012/472396 |
| spellingShingle | Pao-Hwa Lin Jason D. Allen Yi-Ju Li Miao Yu Lillian F. Lien Laura P. Svetkey Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern Journal of Nutrition and Metabolism |
| title | Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern |
| title_full | Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern |
| title_fullStr | Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern |
| title_full_unstemmed | Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern |
| title_short | Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern |
| title_sort | blood pressure lowering mechanisms of the dash dietary pattern |
| url | http://dx.doi.org/10.1155/2012/472396 |
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