Distinct Antiviral Properties of Two Different Bacterial Lysates
Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/8826645 |
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| author | Michael Roth Hanif J. Khameneh Lei Fang Michael Tamm Giovanni A. Rossi |
| author_facet | Michael Roth Hanif J. Khameneh Lei Fang Michael Tamm Giovanni A. Rossi |
| author_sort | Michael Roth |
| collection | DOAJ |
| description | Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs (BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs. |
| format | Article |
| id | doaj-art-6fd6827ffcc24308a6beec43fdc9c8c3 |
| institution | OA Journals |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-6fd6827ffcc24308a6beec43fdc9c8c32025-08-20T02:06:15ZengWileyCanadian Respiratory Journal1198-22411916-72452021-01-01202110.1155/2021/88266458826645Distinct Antiviral Properties of Two Different Bacterial LysatesMichael Roth0Hanif J. Khameneh1Lei Fang2Michael Tamm3Giovanni A. Rossi4Pulmonary Cell Research, DBM University Basel and Pneumology Clinic, University Hospital Basel, Basel, SwitzerlandInstitute for Research in Biomedicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Bellinzona, SwitzerlandPulmonary Cell Research, DBM University Basel and Pneumology Clinic, University Hospital Basel, Basel, SwitzerlandPulmonary Cell Research, DBM University Basel and Pneumology Clinic, University Hospital Basel, Basel, SwitzerlandDepartment of Pediatrics, Pulmonology and Allergy Units, IRCCS Istituto Giannina Gaslini, Genoa, ItalyOral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs (BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs.http://dx.doi.org/10.1155/2021/8826645 |
| spellingShingle | Michael Roth Hanif J. Khameneh Lei Fang Michael Tamm Giovanni A. Rossi Distinct Antiviral Properties of Two Different Bacterial Lysates Canadian Respiratory Journal |
| title | Distinct Antiviral Properties of Two Different Bacterial Lysates |
| title_full | Distinct Antiviral Properties of Two Different Bacterial Lysates |
| title_fullStr | Distinct Antiviral Properties of Two Different Bacterial Lysates |
| title_full_unstemmed | Distinct Antiviral Properties of Two Different Bacterial Lysates |
| title_short | Distinct Antiviral Properties of Two Different Bacterial Lysates |
| title_sort | distinct antiviral properties of two different bacterial lysates |
| url | http://dx.doi.org/10.1155/2021/8826645 |
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