Release kinetics, static and dynamic water contact angles and FTIR data for tissue inhibitor of matrix metalloprotease-1 (TIMP-1) incorporated in electrospun random DegraPol® fibers and TIMP-1 impact on tenocytes and adipose-derived stem cells proliferation and gene expression dataMendeley DataMendeley Data
A first data set refers to tissue inhibitor of matrix metalloprotease-1 (TIMP-1) protein inclusion into a DegraPol® fibres utilizing emulsion electrospinning and the characterization of the random fibre mesh. Specifically, the release kinetics of the protein from the mesh was studied over 7 days. Mo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340925002008 |
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| Summary: | A first data set refers to tissue inhibitor of matrix metalloprotease-1 (TIMP-1) protein inclusion into a DegraPol® fibres utilizing emulsion electrospinning and the characterization of the random fibre mesh. Specifically, the release kinetics of the protein from the mesh was studied over 7 days. Moreover, the static and the dynamic water contact angles were determined. Finally, we assessed Fourier-Transformed Infrared Spectra (FTIR spectra) for DegraPol® with and without TIMP-1.A second data set represents proliferation data obtained with the Alamar Blue Assay, applied on rabbit Achilles tenocytes and rabbit adipose-derived stem cells, when stimulated in vitro with 1, 10, and 100 ng/mL TIMP-1 supplementation compared to the corresponding cell culture without TIMP-1 (control). Furthermore, qPCR was performed and collagen I, ki67, tenomodulin and alkaline phosphatase gene expression data are presented for both cell types in vitro stimulated with 1, 10, and 100 ng/mL TIMP-1 supplementation, respectively, and data are presented as manifold induction compared to a TIMP-1-free cell culture medium (control). |
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| ISSN: | 2352-3409 |